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However, the immune cells can internalize the nanoparticles, leading to cellular functional impairments, degradation of the nanoparticles, and delayed release of drugs from the immune cells. To address these issues, this study introduces an approach for the synthesis of freshly derived neutrophils (NUs)\u2010based nanocarriers system where the NUs are surfaced by dialdehyde alginate\u2010coated self\u2010assembled micelles loaded with mitoxantrone (MIT) and indocyanine green (ICG) (i.e., dA(MI@IPM)s) for stimuli\u2010responsive tumor\u2010targeted therapy. Here, the dA(MI@IPM)s are not internalized by the NUs, but they are anchored on the membrane of the NUs via distearoylphosphatidylethanolamine\u2010polyethylene glycol\u2010polyethylenimine anchors. Owing to the natural recruitment ability of NUs to the tumor microenvironment, NUs\u2010anchored dA(MI@IPM)s accumulation is higher at the tumor site than free dA(MI@IPM)s, where the dA(MI@IPM)s can readily detach from the NUs to get internalized in the tumor cells. The stimuli\u2010responsive dA(MI@IPM)s disassembles inside the cancer cells upon near\u2010infrared irradiation due to the photosensitizing effect of the loaded ICG, releasing MIT and significantly inhibiting tumor growth. This approach is simple and fast to prepare, opening up exciting possibilities for personalized cancer treatment using patient's autologous NUs.<\/jats:p>","DOI":"10.1002\/adhm.202404105","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T23:21:03Z","timestamp":1736983263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Garima","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Biomedical Science &amp; Institute of Bioscience and Biotechnology Kangwon National University  Chuncheon 24341 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanjira","family":"Wangpimool","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science &amp; 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