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During the process of isolating or cuffing the vagus nerve, there is a danger of damaging the nerve itself or the adjacent carotid artery or jugular vein. To minimize this risk, here we introduce a novel hydrogel adhesive\u2010integrated and stretchable microdevice that provides a less invasive,\u00a0 cuff\u2010free option for interfacing with the vagus nerve. The device features a novel hydrogel adhesive formulation that enables crosslinking on biological tissue. The inclusion of kirigami structures within the thin\u2010film microdevice creates space for uniform hydrogel\u2010to\u2010epineurium contact while accommodating the stiffness changes of the hydrogel upon hydration. Using a rodent model, we demonstrate a\u00a0robust device adhesion on a partially exposed vagus nerve in physiological fluid even without the vagus nerve isolation and cuffing process. Our device elicted stable and clear evoked compound action potential (~1500 \u00b5V peak\u2010to\u2010peak) in C\u2010fibers with a current amplitude of 0.4 mA. We believe this innovative platform provides a novel, less\u2010risky approach to interface with fragile nerve and vascular structures during VNS implantation.<\/jats:p>","DOI":"10.1002\/adhm.202404189","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:38:43Z","timestamp":1743737923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hydrogel Adhesive Integrated\u2010Microstructured Electrodes for Cuff\u2010Free, Less\u2010Invasive, and Stable Interface for Vagus Nerve Stimulation"],"prefix":"10.1002","volume":"14","author":[{"given":"Jae Young","family":"Park","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN 47907 USA"},{"name":"Birck Nanotechnology Center Purdue University  West Lafayette IN 47907 USA"},{"name":"Center for Implantable Devices Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongcheon","family":"Lim","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN 47907 USA"},{"name":"Birck Nanotechnology Center Purdue University  West Lafayette IN 47907 USA"},{"name":"Center for Implantable Devices Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Carl R.","family":"Russell","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Lun","family":"Chen","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN 47907 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