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The treatment of myocardial hypertrophy often involves antioxidant stress therapy. In this study, by coordinating curcumin with ferric ions during the synthesis of Prussian blue nanoparticles, a Prussian blue\u2010curcumin (PB\u2010Cur) nanozyme is successfully engineered with exceptional reactive oxygen and nitrogen species (RONS) elimination capabilities. Following PVP modification, the PB\u2010Cur nanozyme exhibited favorable biocompatibility and stability in aqueous solutions. Furthermore, the PB\u2010Cur nanozyme shows remarkable reversible treatment efficacy against myocardial hypertrophy in both in vitro and in vivo models. After one week of treatment, the PB\u2010Cur group in the transverse aortic constriction (TAC)\u2010induced cardiac hypertrophy models displayed a notable decrease in myocardial hypertrophy and fibrosis. Echocardiographic findings also revealed a substantial improvement in cardiac function among TAC mice following PB\u2010Cur administration. Mechanistically, through reactive oxygen species (ROS) elimination, the PB\u2010Cur effectively downregulated oxidative stress\u2010related pathways, including MAPK and PI3K\u2010Akt, which hold promise for treating oxidative stress\u2010related cardiac diseases.<\/jats:p>","DOI":"10.1002\/adhm.202404201","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:42:19Z","timestamp":1745469739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Engineered Prussian Blue\u2010Curcumin Nanozyme with RONS Scavenging Properties for Augmented Reversible Treatment of Cardiac Hypertrophy"],"prefix":"10.1002","volume":"14","author":[{"given":"Anlin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan 450052 P. R. 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