{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:59:46Z","timestamp":1776347986039,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271082"],"award-info":[{"award-number":["82271082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272148"],"award-info":[{"award-number":["82272148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070959"],"award-info":[{"award-number":["82070959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52371254"],"award-info":[{"award-number":["52371254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations of single\u2010gas strategies constrain their therapeutic efficacy. Here, a photoresponsive dual\u2010gas nanomedicine is developed for targeted glaucoma therapy. The nanomedicine, PdH\u2010D\u2010S, is engineered by synthesizing mesoporous palladium hydride (meso\u2010PdH) with efficient hydrogen (H\u2082) storage capacity and abundant pore channels, followed by surface modification with DSPE\u2010mPEG and loading sodium nitroprusside (SNP) as a nitric oxide (NO) donor. PdH\u2010D\u2010S penetrates the cornea to reach IOP\u2010regulating tissues, including the trabecular meshwork and Schlemm's canal. Upon 808\u00a0nm laser excitation, PdH\u2010D\u2010S releases H\u2082 and NO in a controlled manner. H\u2082 activates the AKT\/p\u2010AKT\/eNOS\/sGC signaling pathway, while NO binds to soluble guanylate cyclase (sGC), converting guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), relaxing trabecular meshwork cells and enhancing aqueous humor outflow. This dual\u2010gas system demonstrates high therapeutic efficacy in lowering IOP and offers a mechanistic advancement in glaucoma treatment through synergistic gas therapy.<\/jats:p>","DOI":"10.1002\/adhm.202404245","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T03:44:56Z","timestamp":1742874296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unlocking the Untapped Potential of Photoresponsive Dual\u2010Gas Nanomedicine in Glaucoma Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiamin","family":"Liu","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University NHC Key Laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tian","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University NHC Key Laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University NHC Key Laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7958-0364","authenticated-orcid":false,"given":"Yuan","family":"Lei","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University NHC Key Laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Lei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin 130022 China"},{"name":"University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2023.101223"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030535"},{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1177\/20406223221140392","volume":"13","author":"Liu P.","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph17101261"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114781"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1577"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.09.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03083-4"},{"key":"e_1_2_8_4_2","first-page":"799","volume":"12","author":"Tao Y.","year":"2016","journal-title":"Ther. Clin. Risk Manag."},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1582770"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112049"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(20)30035-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-13342-8.00003-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2023.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.12.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62572"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0809-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05029-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00138-1"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821095-6.00020-3"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.08.041"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106494"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700455"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121074"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5703"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11435"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5703"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.12.017"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19640"},{"key":"e_1_2_8_18_3","first-page":"5153","volume":"65","author":"Du R.","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_18_4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13317"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100922"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5072"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00363.2007"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0513-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211063165"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00503.2014"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.894812"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-019-02782-3"},{"key":"e_1_2_8_23_1","volume-title":"Ocular Transporters and Receptors","author":"Cholkar K.","year":"2013"},{"key":"e_1_2_8_24_1","volume-title":"Methods in Enzymology","author":"Ohta S.","year":"2015"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0359-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6019"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-023-01807-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15172"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-016-1563-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.44.002162"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.52"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202404245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:15:18Z","timestamp":1759756518000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202404245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/adhm.202404245"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202404245","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"assertion":[{"value":"2024-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2404245"}}