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Most therapies and dressings for DFUs focus on one symptom at a time, however, multifunctional smart self\u2010healing hydrogels can withstand multifactorial motional diabetic wounds. Motional wounds are easy\u2010to\u2010split wounds that experience tension, compression, and movement caused by stress now and then. Hyaluronic acid (HA) based self\u2010healing hydrogels stand out among other biomaterials due to their ability to cover irregular wound surfaces, maintain a moist environment, repair themselves when ruptured, and exhibit excellent biocompatibility. These self\u2010healing hydrogels can repair damages caused by movement and recover the functional properties during healing. These hydrogels can also act as therapeutic delivery vehicles and tissue regeneration systems. This review demonstrates the potential of HA\u2010based self\u2010healing hydrogels for diabetic wound healing. Due to its self\u2010healing capabilities, these hydrogels offer a customized therapeutic approach for motional diabetic wounds. The review also critically examines the challenges and future directions for HA\u2010based self\u2010healing hydrogels in diabetic wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202404255","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T23:47:51Z","timestamp":1735170471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Hyaluronic Acid\u2010Based Self\u2010Healing Hydrogels for Diabetic Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Anish","family":"Chhillar","sequence":"first","affiliation":[{"name":"School of Biosciences and Bioengineering Indian Institute of Technology Mandi  Kamand Mandi Himachal Pradesh 175075 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-0404","authenticated-orcid":false,"given":"Amit","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"School of Biosciences and Bioengineering Indian Institute of Technology Mandi  Kamand Mandi Himachal Pradesh 175075 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4909-y"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154766"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00287-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3060013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15983-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpsp.2021.100231","volume":"4","author":"Syauta D.","year":"2021","journal-title":"Med. 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