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Moreover, the limited self\u2010healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin\u2010loaded poly(3\u2010hydroxybutyrate\u2010co\u20104\u2010hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle\u2010loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar\u2010free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full\u2010cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing.<\/jats:p>","DOI":"10.1002\/adhm.202404266","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T02:05:44Z","timestamp":1736561144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management"],"prefix":"10.1002","volume":"14","author":[{"given":"Hanbai","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwei","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H. 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