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The barrier function of the human placenta is performed by villous trophoblasts, i.e. undifferentiated cytotrophoblasts and differentiated syncytiotrophoblats, whose maturation and function are influenced by wall shear stress (WSS) from the maternal blood circulation. Most in vitro placenta models rely on cyclic adenosine monophosphate inducer forskolin (FSK) to establish a placental syncytium. Here a trophoblastic BeWo cell line is used to systematically compare the effect of FSK treatment in static culture with WSS stimulation in a pumpless, recirculating organ\u2010on\u2010chip. It is shown that BeWo cells undergo a similar differentiation under WSS exposure to FSK treatment. A WSS of 0.1 dyn cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    leads to cell fusion, polarization, barrier functions, human chorionic gonadotropin (\u03b2\u2010hCG) secretion, and increased expression of key transporters. Moreover, WSS induces favorable changes in the levels of FMS\u2010like tyrosine kinase\u20101 (FLT\u20101) and Placental Growth Factor (PlGF) suggesting the development of a physiologically relevant placental syncytium\u2010on\u2010chip (PSoC) without the need for FSK. The platform is further expanded to a syncytiotrophoblast\/endothelial co\u2010culture showing physiological vascular functions under WSS. The forskolin\u2010free PSoC presented here represents the first pumpless recirculating and scalable platform for physiological placental studies and drug testing.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404462","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:05:44Z","timestamp":1750248344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Placental Syncytium\u2010on\u2010Chip (PSoC)\u2013Comparison of Forskolin or Mechanical Induced\u2010Syncytialization"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-7229","authenticated-orcid":false,"given":"Ludivine","family":"Delon","sequence":"first","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  P.O. Box 4950 Oslo 0424 Norway"},{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-554X","authenticated-orcid":false,"given":"Mathias","family":"Busek","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  P.O. Box 4950 Oslo 0424 Norway"},{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Duarte","family":"Menezes","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering James Watt School of Engineering University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-846X","authenticated-orcid":false,"given":"Nikolaj","family":"Gadegaard","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering James Watt School of Engineering University of Glasgow  Glasgow G12 8QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Stokowiec","sequence":"additional","affiliation":[{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Golovin","sequence":"additional","affiliation":[{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliia","family":"Boichuk","sequence":"additional","affiliation":[{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-3774","authenticated-orcid":false,"given":"Thomas","family":"Combriat","sequence":"additional","affiliation":[{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"},{"name":"Njord Center PoreLab Department of Physics University of Oslo  Oslo 0371 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-9250","authenticated-orcid":false,"given":"Aleksandra","family":"Aizenshtadt","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  P.O. Box 4950 Oslo 0424 Norway"},{"name":"Hybrid Technology Hub Centre of Excellence Institute of Basic Medical Science University of Oslo  P.O. Box 1110 Oslo 0317 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6992-8091","authenticated-orcid":false,"given":"Stefan","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  P.O. 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