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Salicylic acid (SA) is a classic anti\u2010inflammatory agent for the treatment of RA. To enhance the therapeutic effect of SA, an innovative therapeutic approach for RA is developed by encapsulating polymerized\u2010SA (PSA) nanoparticles within neutrophil membranes. The study demonstrated that neutrophil membranes endowed PSAs with the ability to selectively target inflammatory joints in RA mice, where they\u00a0specifically accumulated within the inflammatory chondrocytes. The internalized PSAs underwent gradual degradation into SA within chondrocytes, facilitating sustained release into the articular cavity and effectively alleviating RA symptoms. By attenuating the expression of inflammatory mediators within the joint cavity and suppressing neutrophil extracellular traps (NETs) in the synovium, neutrophil membrane encapsulated polymerized salicylic acid nanoparticles (N\u2010PSAs) effectively restore long\u2010term intra\u2010articular homeostasis in RA mice, thereby establishing a conducive microenvironment for cartilage repair. In summary, the articular chondrocytes represent an optimal reservoir for therapeutic agents targeting joint disorders. By conferring PSA\u00a0with the capability to specifically target inflammatory chondrocytes, the neutrophil membrane\u2010coated drug\u2010polymerized nanoparticles offer a promising therapeutic strategy for the management of rheumatoid arthritis (RA) and serve as a valuable reference for treating other inflammatory joint disorders.<\/jats:p>","DOI":"10.1002\/adhm.202404510","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:34:14Z","timestamp":1743568454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neutrophil Membrane\u2010Encapsulated Polymerized Salicylic Acid Nanoparticles Effectively Alleviating Rheumatoid Arthritis by Facilitating Sustained Release of Salicylic Acid into the Articular Cavity from Chondrocytes"],"prefix":"10.1002","volume":"14","author":[{"given":"Luying","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial Surgery School of Stomatology The Fourth Military Medical University  Xi\u2019an 710032 P. 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