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Consequently, the development of new, efficient, and non\u2010resistant antimicrobial agents has become a priority for medical practitioners. In this study, a stepwise hydrothermal reaction strategy is utilized to prepare Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MoS<jats:sub>2<\/jats:sub> core\u2013shell nanoparticles (NPs) with photosynthesis\u2010like activity for the treatment of bacterial infections. The Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MoS<jats:sub>2<\/jats:sub> NPs continuously catalyze the production of reactive oxygen species (ROS) from hydrogen peroxide through photosynthesis\u2010like reactions and convert light energy into heat with a photothermal efficiency of 30.30%. In addition, the photosynthetically generated ROS, combined with the iron\u2010induced cell death mechanism of the Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MoS<jats:sub>2<\/jats:sub> NPs, confer them with exceptional and broad\u2010spectrum antibacterial properties, achieving antimicrobial activities of up to 98.62% for <jats:italic>Staphylococcus aureus<\/jats:italic>, 99.22% for <jats:italic>Escherichia coli<\/jats:italic>, and 98.55% for <jats:italic>methicillin\u2010resistant Staphylococcus aureus<\/jats:italic>. The composite exhibits good cell safety and hemocompatibility. Finally, a full\u2010thickness diabetic wound model validates the significant pro\u2010healing properties of Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MoS<jats:sub>2<\/jats:sub> in chronic diabetic wounds. Overall, the design of photosynthesis\u2010inspired Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@MoS<jats:sub>2<\/jats:sub> presents new perspectives for developing efficient photothermal nano\u2010enzymatic compounds, offering a promising solution to the challenges of antimicrobial drug resistance and antibiotic misuse.<\/jats:p>","DOI":"10.1002\/adhm.202404525","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:15:00Z","timestamp":1737368100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Photosynthesis\u2010Inspired NIR\u2010Triggered Fe\u2083O\u2084@MoS\u2082 Core\u2013Shell Nanozyme for Promoting MRSA\u2010Infected Diabetic Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiamu","family":"Xiao","sequence":"first","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuping","family":"An","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Tang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dai","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"},{"name":"Jiangsu Engineering Research Center of Interfacial Chemistry School of Chemistry and Chemical Engineering Nanjing University  163 Xianlin Avenue, Qixia District Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-752X","authenticated-orcid":false,"given":"Donglin","family":"Gan","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Wang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.015"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.06.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306632"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102545"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300710"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202405761"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700527"},{"key":"e_1_2_7_8_1","first-page":"10","volume":"92","author":"Li S. 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