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However, many current studies focus on the instantaneous or short\u2010term adhesion persistence of bioadhesives, and ignore the evaluation of their long\u2010term wet adhesion behaviors which is urgent for keratoplasty repair process. In view of this situation, a dual covalent cross\u2010linking hydrogel (ASO) bioadhesive is developed. The ASO bioadhesive comprised acrylated gelatin(G\u2010AA), thiolated gelatin(G\u2010SH), and oxidized dextran (OD). Introduction of thiol chemistry made the emergence of ASO dual covalent cross\u2010linking controllable by UV light irradiation. The analysis of this feature revealed an intriguing phenomenon. The ASO bioadhesive demonstrated spatially specific control over cross\u2010linking behavior by first penetrating the tissue and then initiating cross\u2010linking, thereby significantly enhancing its long\u2010term wet adhesion ability. The ASO bioadhesive can maintain more than 50% adhesion after being immersed in wet environment for one month. Subsequently, ASO bioadhesive demonstrated long\u2010term wet adhesive stability once again on corneal lamellar transplantation model through maintaining strong anchorage of corneal donor to recipient bed and promoting their integration. The unprecedented adhesive mechanism presented in this study provided innovated theoretical basis for designing bioadhesives with superior long\u2010term wet adhesion.<\/jats:p>","DOI":"10.1002\/adhm.202404557","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:00:54Z","timestamp":1742281254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Enhanced Long\u2010Term Wet Adhesion Strategy of Spatial Control the Emergence of Dual Covalent Cross\u2010Linking for Sutureless Cornea Transplant"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhuhao","family":"Tan","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou 510006 P. R. 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