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However, existing hydrogel dressings suffer from poor breathability and clinically used antimicrobial agents such as antibiotics, metal nanoparticles, and natural antimicrobial substances face challenges including resistance, toxicity, and high extraction costs, respectively. Inspired by the antimicrobial properties of airway surface liquid (ASL), a biomimetic moisturizing and antibacterial hydrogel dressing (BMAHD) is designed. It combines polyvinyl alcohol (PVA) hydrogel with ordinary gauze to achieve high breathability, while also secreting a water\u2010glycerol mixture to moisturize the wound. Interestingly, Na<jats:sub>2<\/jats:sub>CO<jats:sub>3<\/jats:sub> secreted by dressing achieves broad\u2010spectrum bactericidal effects, with up to 99% sterilization rates within 24\u00a0h. Furthermore, co\u2010cultivation experiments with mouse embryonic fibroblasts (L929) and sheep red blood cells (SRBC) demonstrate excellent cellular compatibility of the dressing. To prove of concept, the animal model confirms that BMAHD significantly promotes wound healing. The BMAHD provides a valuable reference for the design of novel medical dressings.<\/jats:p>","DOI":"10.1002\/adhm.202404601","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:01:58Z","timestamp":1739250118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Breathable, Moisturizing Biomimetic Wound Dressing with Broad\u2010Spectrum Antimicrobial Properties"],"prefix":"10.1002","volume":"14","author":[{"given":"Yunge","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University  Beijing 100000 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