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Here, a rational design of nitric oxide (NO) donor N,N'\u2010di\u2010sec\u2010butyl\u2010N,N'\u2010dinitroso\u20101,4\u2010phenylenediamine (BNN6)\u2010based injectable hydrogel, is reported in which the NO release can be triggered by a photothermal effect owing to semiconducting perylene diimide (PDI) J\u2010aggregation fibers. The synthetic PDI derivatives self\u2010assembling into 0D nanoparticles and then aggregating to 1D J fiber is accompanied by absorbance red\u2010shifting from 700 to 790\u00a0nm and then to 852\u00a0nm. After encapsulating BNN6, a \u201csandwich roll\u201d (SR) like structure is evenly crosslinked into an injectable hydrogel (SRH) exhibiting a high photothermal convenience efficiency of 72%, which enables the SRH to achieve highly efficient photocontrol NO release. The SRH shows excellent injectability, shape adaptability, and effective antibacterial efficacy over 99% to the\n                    <jats:italic>E.coli<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . and remarkable in vivo antibiofilm efficiency of 99.58% by laser irradiation. Furthermore, the synergistic treatment displays the ability to eliminate inflammation, facilitate angiogenesis, and promote collagen deposition, thereby significantly stimulating the healing process of wounds. The semiconducting J\u2010aggregation injectable hydrogel can be a versatile strategy for the treatment of biofilm.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404754","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:48:23Z","timestamp":1739249303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Semiconducting Perylene Diimide J\u2010aggregates Cross\u2010linked Hydrogel Enables High\u2010Efficiency Photothermal Controlled Release of Nitric Oxide for Antibiofilm Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Kangxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Strait Institute of Flexible Electronics (SIFE Future Technologies) Fujian Key Laboratory of Flexible Electronics Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE)  Fuzhou 350117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Strait Institute of Flexible Electronics (SIFE Future Technologies) Fujian Key Laboratory of Flexible Electronics Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE)  Fuzhou 350117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Strait Institute of Flexible Electronics (SIFE Future Technologies) Fujian Key Laboratory of Flexible Electronics Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE)  Fuzhou 350117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-0347","authenticated-orcid":false,"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Strait Institute of Flexible Electronics (SIFE Future Technologies) Fujian Key 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