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Herein, the successful design and fabrication of a \u201cwater\u2010insoluble\u201d supramolecular precipitate is reported through the \u201cbottom\u2010up\u201d assembly of polyanion sodium alginate (SA) with the antimicrobial motifs A2G and Cu<jats:sup>2+<\/jats:sup>. This innovative hetero\u2010motif polyionic junction leverages a network of hydrogen bonds aligning with electrostatic interactions, and hydrophobic effects to mitigate the rapid release of active components, providing exceptional long\u2010term antimicrobial efficacy against Staphylococcus aureus (<jats:italic>S. aureus<\/jats:italic>), Escherichia coli (<jats:italic>E. coli<\/jats:italic>), and Candida albicans (<jats:italic>C. albicans<\/jats:italic>). Specifically, it retains an impressive 99.9% efficacy against <jats:italic>S. aureus<\/jats:italic> even after enduring 10 successive wash cycles. The hydroxyl groups in A2G\u2010Cu\u2010SA confer exceptional adhesion to a wide array of substrates. This robust adherence is complemented by its enduring antibacterial properties, with the material maintaining a 99.9% efficacy rate after being submerged in water for an extended period of 100 days. In vivo and in vitro studies substantiate the biocompatibility of A2G\u2010Cu\u2010SA, while its clinical potential is evidenced by the enhanced healing of <jats:italic>S. aureus<\/jats:italic>\u2010infected wounds upon titanium sheet coating. This innovation meets the current need for effective antimicrobials and contributes to sustainable medical advancements.<\/jats:p>","DOI":"10.1002\/adhm.202404791","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:01:14Z","timestamp":1741726874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Covalent Interaction Induced Supramolecular Precipitate with Hetero\u2010Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Xuejiao","family":"Wang","sequence":"first","affiliation":[{"name":"Fujian\u2010Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering Engineering Research Center of Industrial Biocatalysis Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering College of Chemistry and Materials Science Fujian Normal University  Fuzhou Fujian 350007 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianbo","family":"He","sequence":"additional","affiliation":[{"name":"Fujian\u2010Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering Engineering Research Center of Industrial Biocatalysis Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering College of Chemistry and Materials Science Fujian Normal University  Fuzhou Fujian 350007 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanling","family":"He","sequence":"additional","affiliation":[{"name":"Fujian\u2010Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering Engineering Research Center of Industrial Biocatalysis Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering College of Chemistry and Materials Science Fujian Normal University  Fuzhou Fujian 350007 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