{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:01:35Z","timestamp":1792972895962,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["EM\/Dev\/SG\/165\/0103\/2023"],"award-info":[{"award-number":["EM\/Dev\/SG\/165\/0103\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Timely control of bleeding is crucial to reduce mortality in\u00a0traumatic injuries, highlighting the urgent need for biomaterials with anti\u2010hemorrhagic properties. Polycaprolactone (PCL)\u00a0is commonly used for producing nanofibers in the range of 100\u2013200\u00a0nm. However, creating ultrafine PCL nanofibers with diameters below 100\u00a0nm remains a challenge, limiting its potential as a hemostatic bandage. In this study, various ratios of low molecular weight PCL are blended with reduced keratin to modulate the\u00a0solution\u00a0shear\u2010thinning behavior. The optimized blend enables the production of ultrafine nanofibers with a mean diameter of \u224850\u00a0nm, providing a high surface area. The surfaces of these nanofibers demonstrate excellent\u00a0platelet adhesion,\u00a0aggregation, and activation. Additionally, they are\u00a0cytocompatible\u00a0with fibroblasts.\u00a0The ultrathin nanofibers are electrospun on gauze to create a hemostatic product that shows favorable plasma and blood clotting kinetics.\u00a0An\n                    <jats:italic>in<\/jats:italic>\n                    <jats:italic>vivo<\/jats:italic>\n                    \u00a0study\u00a0demonstrates reduced clotting times for nanofiber\u2010based products compared to plain gauze. Mechanistically, the RBCs on the nanofiber composites attain a\u00a0polyhedral shape reducing the space between them and creating a compact seal to prevent fresh blood from oozing out. The intrinsic hemostatic properties of keratin,\u00a0combined with reduced\u00a0fiber diameter and the hydrophilic nature of gauge make this a promising hemostatic bandage.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404814","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:37:19Z","timestamp":1741747039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultrathin Nanofibers Ameliorate Commercial Gauze for Rapid Hemorrhage Control Via Improved Clotting Kinetics and Rbc Modulation"],"prefix":"10.1002","volume":"14","author":[{"given":"Shivangi","family":"Parhi","sequence":"first","affiliation":[{"name":"CSIR\u2010 Indian Institute of Chemical Biology  4, Raja S.C. Mullick Road Kolkata West Bengal 700032 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashmita","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"CSIR\u2010 Indian Institute of Chemical Biology  4, Raja S.C. Mullick Road Kolkata West Bengal 700032 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Das","sequence":"additional","affiliation":[{"name":"School of Bioscience and Engineering Jadavpur University  188, Raja Subodh Chandra Mallick Rd, Jadavpur Kolkata West Bengal 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samsamul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery &amp; Radiology West Bengal University of Animal and Fishery Sciences  Belgachia Kolkata West Bengal 700037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R","family":"Vaishak","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery &amp; Radiology West Bengal University of Animal and Fishery Sciences  Belgachia Kolkata West Bengal 700037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Biswas","sequence":"additional","affiliation":[{"name":"School of Medical Sciences and Technology Indian Institute of Technology Kharagpur  Kharagpur West Bengal 721302 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvro Sankha","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Tata Medical Center  Action Area I, Newtown Kolkata West Bengal 700160 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samit Kumar","family":"Nandi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery &amp; Radiology West Bengal University of Animal and Fishery Sciences  Belgachia Kolkata West Bengal 700037 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Dhara","sequence":"additional","affiliation":[{"name":"School of Medical Sciences and Technology Indian Institute of Technology Kharagpur  Kharagpur West Bengal 721302 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyali","family":"Basak","sequence":"additional","affiliation":[{"name":"School of Bioscience and Engineering Jadavpur University  188, Raja Subodh Chandra Mallick Rd, Jadavpur Kolkata West Bengal 700032 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujoy K.","family":"Das","sequence":"additional","affiliation":[{"name":"CSIR\u2010 Indian Institute of Chemical Biology  4, Raja S.C. Mullick Road Kolkata West Bengal 700032 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-8882","authenticated-orcid":false,"given":"Paulomi","family":"Ghosh","sequence":"additional","affiliation":[{"name":"CSIR\u2010 Indian Institute of Chemical Biology  4, Raja S.C. Mullick Road Kolkata West Bengal 700032 India"},{"name":"Institute of Health Sciences Presidency University  Plot No. DG\/02\/02, Action Area 1D, Newtown Kolkata West Bengal 700156 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2017.03.002"},{"key":"e_1_2_8_2_1","first-page":"4","volume-title":"Biocomposites","author":"Aghayari S.","year":"2022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604646"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201700269"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2005.03.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2015.11.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pi.2387"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3py01401k"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02670"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2022.102683"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIA.2011.2127431"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201000188"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0374"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aaa637"},{"key":"e_1_2_8_15_1","author":"Gruber S. M. S.","year":"2019","journal-title":"JoVE"},{"key":"e_1_2_8_16_1","first-page":"35","volume":"2017","author":"Colmenares G.","year":"2017","journal-title":"Revista Facultad de Ingenieria"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318169cd3c"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09108"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0110-5558.72416"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.03.038"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118541"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM00411G"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elsc.201900105"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4IB00208C"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/1116\/1\/012024"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.03.034"},{"key":"e_1_2_8_27_1","volume":"2","author":"Ajay Sharma L.","year":"2020","journal-title":"Open Acc. J. Biomed. Sci."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2012.0671"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.49862"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33172"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8074080"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1653"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111994"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200290"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.04.018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR01148K"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB01109E"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2015.1064881"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31251"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00654-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.3814.3814"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2019.106286"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.23232"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm500091e"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA03373G"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00923"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202404814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202404814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202404814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:08:46Z","timestamp":1770455326000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202404814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/adhm.202404814"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202404814","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"2024-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2404814"}}