{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:30:12Z","timestamp":1787981412640,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302662"],"award-info":[{"award-number":["82302662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771502"],"award-info":[{"award-number":["81771502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273265"],"award-info":[{"award-number":["82273265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["2018KY473"],"award-info":[{"award-number":["2018KY473"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photothermal therapy (PTT) combined with chemotherapy using hydrogel as a delivery platform is considered a promising strategy for the treatment of advanced colorectal cancer (CRC). However, maintaining the stability of photo\u2010absorbing agents (PTA) in the hydrogel and ensuring that the hydrogel remains anchored to the tumor tissue presents significant challenges. Herein, this work introduces an injectable 2D molybdenum disulfide (2D\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010integrated adhesive hydrogel, specifically N\u2010(2\u2010aminoethyl)\u20104\u2010(4\u2010(hydroxymethyl)\u20102\u2010methoxy\u20105\u2010nitro\u2010sophenoxy) butanamide\u2010linked sodium alginate\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    \u20105\u2010fluorouracil (AlgNB\/MoS\n                    <jats:sub>2<\/jats:sub>\n                    \/5\u2010FU). This hydrogel functions as a near\u2010infrared light (NIR)\u2010triggered photothermal and drug\u2010delivery implant for CRC treatment. The MoS\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets maintain superior dispersibility in the hydrogel and exhibit a highly efficient NIR\u2010triggered photothermal effect. Importantly, the aldehyde group in AlgNB also imparted tissue adhesion to the hydrogel, the adhesive hydrogel is used to infiltrate and anchor within tumor tissue. The injectable adhesive AlgNB\/MoS\n                    <jats:sub>2<\/jats:sub>\n                    \/5\u2010FU hydrogel shows remarkable efficacy in inhibiting SW480 cells proliferation and promoting colorectal tumor regression by triggering PTT and delivering the 5\u2010FU drug in both in vitro and in vivo studies. The potential synergistic mechanism of PTT and 5\u2010FU chemotherapy may contribute to inhibiting DNA repair and enhancing a robust immune response. Therefore, this research provides valuable strategic insights for the synergistic treatment of localized CRC.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404842","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T02:14:51Z","timestamp":1742177691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Injectable 2D\u2010MoS\n                    <sub>2<\/sub>\n                    \u2010integrated Bioadhesive Hydrogel as Photothermal\u2010Derived and Drug\u2010Delivery Implant for Colorectal Cancer Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-4909","authenticated-orcid":false,"given":"Xiaojun","family":"Long","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Key Laboratory of Biological Treatment of Zhejiang Province Sir Run Run Shaw Hospital School of Medicine Zhejiang University  Hangzhou 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