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In this study, a tissue\u2010adhesive and antibacterial hydrogel incorporating MXene and deferoxamine (DFO)\u2010loaded microspheres is developed for the treatment of MDR bacteria\u2010infected diabetic wounds. The hydrogel is built based on covalent crosslinking between \u03b5\u2010poly(L\u2010lysine) and\n                    <jats:italic>o<\/jats:italic>\n                    \u2010phthalaldehyde\u2010terminated four\u2010arm poly(ethylene glycol). The hydrogel exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, and biodegradability. Under near\u2010infrared (NIR) irradiation, the MXene converted light into heat and elevated the local temperature rapidly, enabling the rapid disintegration of MDR bacterial biofilms. Simultaneously, the hydrogel exerted inherent antibacterial activity, persistently killing planktonic bacteria, and effectively controlling wound infections. The encapsulated DFO is then released from the hydrogel in a sustained and controlled manner, and promoted angiogenesis during diabetic wound healing. Additionally, MXenes can scavenge excessive reactive oxygen species and alleviate wound inflammation. In the methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010infected diabetic wound model in mice, the composite hydrogel along with NIR irradiation efficiently reduced the infectious bacteria, and accelerated the wound healing by promoting angiogenesis and alleviating inflammation. This composite hydrogel has great clinical potential for the treatment of diabetic wounds, particularly in challenging healing environments involving motion and infection.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404889","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T01:23:31Z","timestamp":1739323411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tissue\u2010Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria\u2010Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis"],"prefix":"10.1002","volume":"14","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Burn Surgery First Hospital of Jilin University  Changchun 130021 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