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Here, this investigation aims to develop and evaluate ABSi\u2010148, a novel near\u2010infrared (NIR) agent targeting hypoxic carbonic anhydrase IX (<jats:italic>CA IX<\/jats:italic>), for its potential applications in ICT imaging and even PDAC treatment. ABSi\u2010148 is synthesized from 4\u2010(2\u2010Aminoethyl) benzene sulfonamide (ABS), a sulfonamide derivative, conjugating with MHI\u2010148 dye with merits of exceptional NIR\u2010emitting traits, high biocompatibility, and deep tissue penetration imaging capability. It selectively accumulates in CoCl<jats:sub>2<\/jats:sub>\u2010induced pancreatic stellate cells and pancreatic cancer cells via binding with transmembrane <jats:italic>CA IX<\/jats:italic> in vitro. Meanwhile, ABSi\u2010148 effectively visualizes the early pancreatic lesion, and its long\u2010term administration inhibits the progression of hypoxia\u2010related fibrosis involved in pancreatic intraepithelial neoplasias (PanINs), and even PDAC progression in vivo. Besides, ABSi\u2010148 monitors treatment efficacy and localizes hypoxic tumor regions, enhancing survival in tamoxifen combined with caerulein\u2010induced KPC mice. Overall, ABSi\u2010148 emerges as a theranostic NIR agent for precise diagnosis and targeted therapy in ICT of PDAC, promising to alleviate tumor progression and enhancing outcomes.<\/jats:p>","DOI":"10.1002\/adhm.202404935","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:24:23Z","timestamp":1742275463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Near\u2010Infrared Imaging Agent ABSi\u2010148 Alleviates <i>CA IX<\/i>\u2010Mediated Hypoxic Fibrosis in Inflammation\u2010Cancer Transition"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-9715","authenticated-orcid":false,"given":"Zhi","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shenzhen People's Hospital (The Second Clinical Medical College Jinan University The First Affiliated Hospital Southern University of Science and Technology) 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