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Therefore, regulating neutrophil recruitment becomes an attractive therapeutic approach for neutrophil\u2010mediated inflammation. Here, the impact of salicylic acid\u2010based polymeric particles in regulating neutrophil recruitment in vivo and in vitro, particularly investigating the impact of neutrophil targeting via particle geometry\u2010driven phagocytosis is explored. It is found that rod\u2010shaped polymeric particles can improve neutrophil targeting in a murine ALI model, effectively preventing neutrophil infiltration into the mice's lungs compared to spherical particles of the same volume. It is demonstrated that the elongated nature of the polymeric carriers reduced neutrophils\u2019 transmigration ability across endothelial barriers in vivo and in vitro, contributing to their therapeutic effectiveness. These data represent initial work in developing non\u2010spherical particle\u2010mediated targeting of activated neutrophils for conditions affected by neutrophilic injury.<\/jats:p>","DOI":"10.1002\/adhm.202404955","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:17:00Z","timestamp":1748333820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rod\u2010shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation"],"prefix":"10.1002","volume":"14","author":[{"given":"M. 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