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Various strategies have been proposed to equip bone implants with antibacterial properties to prevent infection. However, the cytotoxicity associated with antimicrobial effects adversely impacts the osseointegration. Herein, a facile and safe strategy is proposed to endow bone implants with infection prevention, good cytocompatibility, inflammatory\u2010responsive antimicrobial properties, thus promoting bone healing. The coating is fabricated on the implant through both covalent and non\u2010covalent bonds of polyphenols with chlorhexidine (CHX). The covalent bonds guarantee long\u2010term stability, while non\u2010covalent bonds facilitate early release of CHX. Furthermore, the inclusion of polyphenols reduces the electrophilicity of CHX, inhibits reactive oxygen species generated by CHX, and minimizes interference with the mitochondrial electron transport chain, thereby reducing cellular toxicity. Consequently, the coating effectively fortified the bone implant, successfully impeding bacterial invasion within 7 days in Sprague\u2010Dawley rats and suppressing inflammation as well as bone resorption caused by bacteria during a 60\u2010day femoral implantation, thus facilitated osseointegration on the implant. The study investigated the cytotoxicity associated with mitochondrial interference induced by CHX and proposed a strategy to enhance its cellular compatibility, thereby providing a novel approach for fabricating biocompatible antibacterial bone implants.<\/jats:p>","DOI":"10.1002\/adhm.202404958","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:00:58Z","timestamp":1745470858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Engineering Antibacterial, Biocompatible, Anti\u2010Oxidant Titanium\u2010Based Implants Using Polyphenols\u2010Chlorhexidine Networks for Bone Regeneration"],"prefix":"10.1002","volume":"14","author":[{"given":"Yankai","family":"Wang","sequence":"first","affiliation":[{"name":"Key Lab. of Oral Diseases Research of Anhui Province College &amp; Hospital of Stomatology Anhui Medical University  81 Meishan Road Hefei 230032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Hong","sequence":"additional","affiliation":[{"name":"Key Lab. of Oral Diseases Research of Anhui Province College &amp; 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