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Current treatments emphasize early revascularization to restore blood supply to the myocardium, often overlooking the extensive oxidative damage and autophagy dysfunction resulting from reactive oxygen species (ROS) release after MI. Therefore, timely and effective interventions to clear ROS in the early stages of MI are crucial for inhibiting the MI pathological progression and restoring cardiac function. This study constructed a ROS\u2010responsive biomimetic nanoparticle (PNP@Nb\n                    <jats:sub>2<\/jats:sub>\n                    C\u2010MSN) by integrating niobium carbide MXenes (Nb\n                    <jats:sub>2<\/jats:sub>\n                    C) onto mesoporous silica nanoparticle (MSN) coated with platelet membrane. During the MI acute phase, these nanoparticles are targeted and delivered to the infarcted heart via intravenous injection. The MSN mesoporous structure enhances the ROS scavenging capacity of Nb\n                    <jats:sub>2<\/jats:sub>\n                    C, eliminating excess ROS in the infarct region and inhibiting the oxidative stress progression. Silicon ions released from MSN further promote angiogenesis within the infarct region. PNP@Nb\n                    <jats:sub>2<\/jats:sub>\n                    C\u2010MSN reduces inflammation by downregulating the NF\u2010\u03baB pathway and enhances autophagy by activating the AMPK pathway, thereby blocking pathological microenvironmental progression after MI and improving cardiac function. In vitro and in vivo results highlight the therapeutic potential of PNP@Nb\n                    <jats:sub>2<\/jats:sub>\n                    C\u2010MSN in MI, offering a\u00a0promising MI treatment strategy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404979","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:12:48Z","timestamp":1745993568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Targeted Anti\u2010Inflammatory Nanozymes with Pro\u2010Angiogenic Activity for Myocardial Infarction Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Wenling","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Hubei Provincial Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology) Ministry of Education  Wuhan Hubei 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Hubei Provincial Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology) Ministry of Education  Wuhan Hubei 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 P. 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