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Gallium\u2010based liquid metal (LM) antibacterial agents show promise due to their non\u2010inducement of resistance, though their efficacy remains limited. Here, we graft copper onto nano\u2010LM surfaces via ultrasonication to create copper\u2010modified LM nanoparticles (Cu\u2010LMNPs) with enhanced antibacterial properties. Specific experiments suggest that Cu\u2010LMNPs enhance antibacterial efficacy against ampicillin\u2010resistant <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>MRSA<\/jats:italic>) in vitro, achieving \u2248100% antibacterial effectiveness. The remarkable antibacterial efficacy stems from the considerable increase in Cu<jats:sup>2<\/jats:sup>\u207a and Ga<jats:sup>3<\/jats:sup>\u207a concentrations. Further, the Cu\u2010LMNPs and epidermal growth factors (EGF) are incorporated into the rheology\u2010tunable hydrogels with excellent printability and biocompatibility for accelerating chronically infected wound healing. In vivo experiments demonstrate that the hydrogel patches effectively treated <jats:italic>MRSA<\/jats:italic>\u2010infected wounds in mice. Sustained release of multiple ions and EGF promotes epithelial regeneration, collagen deposition, and neovascularization, making the wound markedly distinct from the control group and nearly fully healed within 10 days. Overall, this research presents a novel 3D\u2010printed mesh hydrogel patch that not only combats bacterial infections but also accelerates wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202404986","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:17:27Z","timestamp":1744885047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["3D\u2010Printed Hydrogel Patches Embedded with Cu\u2010Modified Liquid Metal Nanoparticles for Accelerated Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Materials Research &amp; Center of Double Helix Shenzhen International Graduate School, Tsinghua University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Shan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education, and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics  Nanjing 210016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-9633","authenticated-orcid":false,"given":"Hongzhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Materials Research &amp; Center of Double Helix Shenzhen International Graduate School, Tsinghua University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804187"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119267"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210145"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01850"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00041F"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/2752-5724\/ac7068"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07861"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104298"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat7520"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070748"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9090416"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c15497"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.02.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/175760b0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109873"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05664"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119706"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-021-00289-w"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2023.06.042"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b00009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11664-019-07688-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c01169"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c03695"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202407934"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-3029-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4261"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat2544"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03353-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700701"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202404986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:30:31Z","timestamp":1759761031000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202404986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":30,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/adhm.202404986"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202404986","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2025-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2404986"}}