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In this study,\n                    <jats:bold>TBC<\/jats:bold>\n                    , a novel multi\u2010signal fluorescent probe is presented, crafted for simultaneous differentiation and in situ real\u2010time monitoring of homocysteine (Hcy), cysteine (Cys), sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ), and glutathione (GSH), illuminating the dynamic metabolic status of endogenous reactive sulfur species.\n                    <jats:bold>TBC<\/jats:bold>\n                    achieves an ultrahigh signal\u2010to\u2010background ratio, enabling wash\u2010free direct fluorescence imaging of the dynamics and distribution of these entities in living cells and zebrafish. Notably,\n                    <jats:bold>TBC<\/jats:bold>\n                    has revealed distinctive dynamic metabolic features of Hcy\/Cys\/SO\n                    <jats:sub>2<\/jats:sub>\n                    \/GSH during apoptosis and ferroptosis. This innovative probe acts as a key tool for unraveling the conversion networks of multiple reactive sulfur species and assessing the impact of metabolic oscillations during programmed cell death and the progression of diverse diseases, effectively uncovering concurrent biochemical dynamics in various biological settings and cell death events.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202404993","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:34:25Z","timestamp":1746272065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multifunctional Fluorescent Probes for Profiling Cys, Hcy, GSH, and SO\u2082: Illuminating Their Dynamics in Apoptosis and Ferroptosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Guoxing","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Urology The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University\/Hunan Cancer Hospital  Changsha 410013 P. 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