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Thanks to its high biocompatibility, polyimide\n                    <jats:italic>poly<\/jats:italic>\n                    (biphenyl dianhydride)\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010phenylenediamine (BPDA\u2010PDA) represents a suitable material to fabricate ultrathin and ultra\u2010flexible neural implants. This study explores the surface functionalization of BPDA\u2010PDA, the electrically inert component of the neural implant. The novelty of this approach relies on the fact that dexamethasone (DEX covalently bound to BPDA\u2010PDA, enabling its sustained release over a period of at least 9 weeks. In vitro assays demonstrate that this strategy reduce the production of pro\u2010inflammatory markers in macrophages. In addition, the biocompatibility of the functionalized material has been ensured by evaluating the viability of dorsal root ganglia (DRG) neurons. Furthermore, in vivo implantation of DEX functionalized BPDA\u2010PDA substrates shows a significant reduction in inflammatory cell infiltration and fibrotic capsule thickness formed around the devices. These findings suggest that local release of DEX from the electrically inactive scaffold of neural implants may enhance their long\u2010term stability and performance by mitigating the FBR.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202405004","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:50:07Z","timestamp":1750215007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-8279","authenticated-orcid":false,"given":"Giulia","family":"Turrin","sequence":"first","affiliation":[{"name":"Department of Environmental and Prevention Sciences University of Ferrara  Via Luigi Borsari, 46 Ferrara 44121 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8478-2939","authenticated-orcid":false,"given":"Jose","family":"Crugeiras","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences Department of Cell Biology Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Av. 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