{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:01:37Z","timestamp":1788746497376,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373263"],"award-info":[{"award-number":["52373263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873064"],"award-info":[{"award-number":["51873064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1418200"],"award-info":[{"award-number":["20ZR1418200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interventional catheter, a medical device characterized by a gradient hardness from one end to the other, exhibits enhanced flexibility upon insertion into the human body. This unique configuration accommodates various anatomical structures and surgical requirements. This study reports, for the first time, a degradable hydrogel interventional catheter with gradient hardness. A novel aqueous reaction methodology is developed, enabling the direct transformation of a solid sodium alginate (SA) film strip into a hollow hydrogel interventional catheter. This process involves copper ions\u2010induced asymmetry crosslinking in an aqueous solution, solvent exchange in ethanol, removal of copper ions by ethylenediaminetetraacetic acid, and subsequent bimetallic crosslinking in CaCl<jats:sub>2<\/jats:sub> and FeCl<jats:sub>3<\/jats:sub> aqueous solutions. This method results in gradient\u2010hardness hydrogel interventional catheters without surface defects such as protrusions and pits. The hydrogel interventional catheter demonstrates gradient robustness with mechanical strength reaching 5.5\u00a0MPa for the soft head and 28\u00a0MPa for the hard tail. By incorporating a gradual stiffness variation, the hydrogel catheter with superior lubricity and flexibility more effectively adapts to the anatomical structures of the human body, potentially minimizing tissue damage and expediting surgical procedures. Consequently, it shows significant potential as a medical interventional catheter.<\/jats:p>","DOI":"10.1002\/adhm.202405086","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T01:32:23Z","timestamp":1745803943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Degradable Alginate Hydrogel Intervention Catheters with Gradient Hardness in Length"],"prefix":"10.1002","volume":"14","author":[{"given":"Bingbing","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Fifth People's Hospital Fudan University  Shanghai 201100 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0501-6162","authenticated-orcid":false,"given":"Lidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2024.134779"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.11.090"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.201701169"},{"key":"e_1_2_8_4_1","first-page":"17","volume":"19","author":"Wang D.","year":"2002","journal-title":"Chin. J. Biomed. Eng."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB03280J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.070"},{"key":"e_1_2_8_7_1","first-page":"94","volume":"22","author":"Amstutz C.","year":"2023","journal-title":"Biomed. Eng."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/MRA.2016.2582718"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2004.12.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103277"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2020.108757"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2022.101491"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2023.02.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200115"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01293"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b02532"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2MH00314G"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.11.018"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202108845"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40242-021-1267-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00453"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-00442-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9MH00793H"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102685"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001485"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab7e76"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14997-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01189G"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201913574"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC05396K"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC05947D"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151906"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136398"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.02.072"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c05019"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01409-3"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.480382"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.112746"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810127"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043995"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15143012"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202205229"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2011.06.009"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004579"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.02.069"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303728"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005314"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34677-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206242"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202405086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:24:27Z","timestamp":1759789467000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202405086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":50,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/adhm.202405086"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202405086","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,27]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2405086"}}