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In this study, a non\u2010decellularized cryopreserved aortic allograft (CAo) is investigated as a scaffold for tracheal cartilage regeneration. Originally used to reconstruct infected aortas, CAo retains key features of a large artery\u2014abundant elastic fibers and smooth muscle cells\u2014and demonstrates favorable in vitro biocompatibility with chondrocytes. A trachea\u2013CAo patch construct maintains tensile properties comparable to native trachea and tolerates normal expiratory forces. In a rabbit patch\u2010defect model, CAo elicits only a mild\u2010to\u2010moderate immune response that gradually subsides. Within one month of implantation, robust neocartilage formation is observed, along with angiogenesis and epithelial regeneration. Over the next 12 months, the original aortic scaffold progressively degrades, while newly formed cartilage\u2014originating from recipient perichondrial chondroprogenitor cells\u2014replaces it. 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