{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:02:01Z","timestamp":1792612921048,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1104700"],"award-info":[{"award-number":["2022YFA1104700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["31971373"],"award-info":[{"award-number":["31971373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82102229"],"award-info":[{"award-number":["82102229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic inflammatory myopathy (IIM) is an autoimmune disease that characterized by non\u2010purulent inflammation of the skeletal muscle. However, due to the limitation of study model that can recapitulate the complex pathological process of IIM, the pathogenesis of IIM is still not fully clear. This manuscript develops a vascularized muscle tissue model on a chip that allows to model the immunity mediated pathological changes in IIM. This vascularized muscle model is constructed by layer\u2010by\u2010layer assembly, which could coculture of endothelial cells, myoblasts, and monocytes in a perfusable 3D system. The vascularized muscle model exhibits good biofunctions, including muscle cells alignment and fusion, myofibers generation, force production and expression of muscular biomarkers (myosin heavy chains 1, myosin heavy chains 7, actinin alpha 2, myogenin, and Desmin). Exposure to perfusion of activated monocytes, this work observes the functional changes of muscle tissue, which referred to myofibers atrophy, inflammatory response, and downregulated expression of muscle mature marker, consistent with clinical features of IIM. This work provides a unique platform for modelling IIM and paves a promising avenue for myopathies study and drug testing.<\/jats:p>","DOI":"10.1002\/adhm.202405111","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:19:46Z","timestamp":1747117186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modeling Idiopathic Inflammatory Myopathy in the Bioinspired Muscle Tissue on Chip"],"prefix":"10.1002","volume":"14","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Deng","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China  Hefei 230026 China"},{"name":"Suzhou Institute for Advanced Research University of Science and Technology of China  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Dalian Medical University  Dalian 116000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Dalian Medical University  Dalian 116000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-6436","authenticated-orcid":false,"given":"Jianhua","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"University of Science and Technology of China  Hefei 230026 China"},{"name":"Suzhou Institute for Advanced Research University of Science and Technology of China  Suzhou 215123 China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine Chinese Academy of Sciences  Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0410"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.101484"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30254-0"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)81253-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3041"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.5414\/NP301077"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12380"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.48"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v11.i12.1065"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116995"},{"key":"e_1_2_9_5_3","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8241367"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2022.2137968"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.03.011"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"e_1_2_9_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.11.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd9502"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa459"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00321-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.04.003"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma13112483"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036173"},{"key":"e_1_2_9_11_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.09.057"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003832"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03093-6"},{"key":"e_1_2_9_12_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02158.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0044-8"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051084"},{"key":"e_1_2_9_13_3","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2021.2000584"},{"key":"e_1_2_9_13_4","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01017-7"},{"key":"e_1_2_9_13_5","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12194"},{"key":"e_1_2_9_13_6","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0658-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100182RR"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00204.2014"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.02.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12451"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1699059"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051084"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00553B"},{"key":"e_1_2_9_17_2","volume":"15","author":"Kim H.","year":"2022","journal-title":"Biofabrication"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12524"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12736"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9209"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.28608A"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.03.015"},{"key":"e_1_2_9_22_1","first-page":"1718","volume":"20","author":"Kalovidouris A.","year":"1993","journal-title":"J. Rheumatol."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.01.005"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90400-W"},{"key":"e_1_2_9_23_3","doi-asserted-by":"publisher","DOI":"10.1002\/art.23884"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2788-5"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202405111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:56:14Z","timestamp":1759744574000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202405111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":51,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/adhm.202405111"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202405111","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2405111"}}