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However, the isolation and storage of sEVs lead to issues including lipid membrane disruption, protein denaturation, and nucleic acid degradation. Herein, a surface functionalization strategy is reported for encapsulating single sEV into selectively disassemblable protective shells composed of metal\u2010phenolic networks (MPNs) post\u2010modified with poly(ethylene glycol) (PEG). Disassemblable MPN shells can be rapidly deposited on sEVs in a one\u2010step manner and post\u2010modified with PEG. These coatings enhance the colloidal stability of sEVs and protect them against harsh storage conditions, while the non\u2010covalent and selectively disassemblable nature of the MPN shell allows recovery after storage without compromising their surface integrity and functionality. It is demonstrated that various triggers, such as pH adjustment, competitive chelation, and redox reactions, can be used to disassemble the MPN shell, thereby offering widely adoptable strategies depending on the target applications. This approach potentially overcomes conventional challenges associated with sEV processing and storage and may contribute to reducing cold\u2010chain requirements and transportation costs of future sEVs\u2010based therapeutics and diagnostics.<\/jats:p>","DOI":"10.1002\/adhm.202405188","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T03:40:01Z","timestamp":1746502801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal\u2010Phenolic Networks"],"prefix":"10.1002","volume":"14","author":[{"given":"Chenyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Materials Engineering The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 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