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Persistent bacterial biofilms are a critical obstacle to wound healing, necessitating their effective elimination to promote rapid recovery. In photodynamic antimicrobial therapy (PDAT), enhancing the interaction between the photosensitizer and bacterial biofilms is key to achieving efficient antimicrobial and antibiofilm effects. Here, a novel dissolvable microneedle patch containing a benzoxaborole (\n                    <jats:bold>BOB<\/jats:bold>\n                    )\u2010functionalized photosensitizer is designed,\n                    <jats:bold>TPI\u2010BOB<\/jats:bold>\n                    , for bacteria\u2010specific targeting and localized PDAT of multidrug\u2010resistant biofilm infections in diabetic wounds.\n                    <jats:bold>TPI\u2010BOB<\/jats:bold>\n                    integrates a\n                    <jats:bold>BOB<\/jats:bold>\n                    moiety for selective bacterial binding and a pyridine\u2010based cationic group to enhance electrostatic interactions, showing superior antimicrobial activity in Gram\u2010positive bacteria, particularly\n                    <jats:italic>MRSA<\/jats:italic>\n                    . To further optimize therapeutic delivery and combat biofilm\u2010associated infections,\n                    <jats:bold>TPI\u2010BOB<\/jats:bold>\n                    is incorporated into dissolvable microneedles, which rapidly disintegrate upon application to wound sites. This microneedle system facilitates localized, efficient delivery of\n                    <jats:bold>TPI\u2010BOB<\/jats:bold>\n                    to bacterial biofilms, where it triggers photodynamic action under white\u2010light irradiation. This treatment eradicates the biofilm, initiating tissue repair that reduces inflammation, promotes collagen deposition, and stimulates angiogenesis, accelerating healing. This work presents a novel strategy combining PDAT with microneedle\u2010mediated drug delivery, offering a promising approach for treating diabetic wounds and other biofilm\u2010related infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202405190","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:48:03Z","timestamp":1744267683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dissolving Microneedles Embedded with Photosensitizers for Targeted Eradication of Gram\u2010Positive Bacteria in Multidrug\u2010Resistant Biofilms in Diabetic Wound Infections"],"prefix":"10.1002","volume":"14","author":[{"given":"Ruyan","family":"Xie","sequence":"first","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 P. R. 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