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The inner adhesive layer hydrogel (PT) is prepared by mixing polyethyleneimine (PEI) and thioctic acid (TA). The outer layer (HP) hydrogel is fabricated by the conjugation reaction of thermoresponsive zwitterionic hyaluronic acid, phenylboronic acid, and epigallocatechin gallate complex and polyvinyl alcohol based on dynamic boronic ester bond. The PEI\/TA layer enhances attachment to moist tissue surfaces in vivo, and the anti\u2010adhesive layer HP hydrogel promotes biocompatibility and anti\u2010inflammation while minimizing protein adsorption and improving mechanical stability. The bilayer hydrogel (HPPT) exhibited rapid gelation, robust adhesion in dynamic and moist environments, superior viscoelastic properties and cellular biocompatibility. A mouse\u2010cecum abdominal wall adhesion model is utilized to evaluate efficacy, and the HPPT hydrogel shows local retention, anti\u2010inflammatory effect, and inhibits fibrin deposition while minimizing adhesion formation. These findings highlight the innovative structural and functional properties of the HPPT hydrogel, positioning it as a promising therapeutic barrier in peritoneal surgery aimed at reducing postoperative adhesions and enhancing surgical outcomes.<\/jats:p>","DOI":"10.1002\/adhm.202405238","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T13:27:20Z","timestamp":1741440440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Dual\u2010Layer Hydrogel Barrier Integrating Bio\u2010Adhesive and Anti\u2010Adhesive Properties Prevents Postoperative Abdominal Adhesions"],"prefix":"10.1002","volume":"14","author":[{"given":"Mena Asha","family":"Krishnan","sequence":"first","affiliation":[{"name":"Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha NE 68198 USA"},{"name":"Division of Cardiovascular Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olawale A.","family":"Alimi","sequence":"additional","affiliation":[{"name":"Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha NE 68198 USA"},{"name":"Division of Cardiovascular Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Kuss","sequence":"additional","affiliation":[{"name":"Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical Center  Omaha NE 68198 USA"},{"name":"Division of Cardiovascular Medicine Department of Internal Medicine University of Nebraska Medical Center  Omaha NE 68198 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany N","family":"Razabdouski","sequence":"additional","affiliation":[{"name":"H. 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