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Even though affordable and permeable polyurethane (PU) dressings are widely used in clinical practice, their pure shielding function appears ineffective for contaminated wounds. Herein, an ultrafast laser is utilized to fabricate micro\/nanostructures in PU dressings to significantly enhance drug loading capacity. In contrast to untreated areas, the laser direct writing with spatiotemporal regulation method enhances the drug loading capacity by 61 times. The anti\u2010infective capability is demonstrated by embedding clindamycin within the PU films, indicating that laser\u2010induced micro\/nanostructured PU dressings (PU\u2010MS) not only exhibit stable mechanical properties and biocompatiability, but also produce an obvious inhibition zone of <jats:italic>Staphylococcus aureus<\/jats:italic> in vitro. Furthermore, a rat skin wound infection model verified that PU\u2010MS can effectively prevent bacteria\u2010associated wound infection and SIRS, promoting wound healing. The results show that PU\u2010MS offers considerable potential for various clinical applications, providing a new strategy for the development of advanced medical dressings.<\/jats:p>","DOI":"10.1002\/adhm.202405281","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:54:00Z","timestamp":1746176040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010Infective Polyurethane Dressings via Ultrafast Laser Micro\/Nanostructuring"],"prefix":"10.1002","volume":"14","author":[{"given":"Liang","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Department of Emergency Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 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