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Nanozyme\u2010incorporated hydrogels have shown potential to facilitate diabetic wound repair. This study developed a polyphenol\u2010conductive nanozyme\u2010enhanced redox hydrogel composed of dopamine\u2010grafted fish gelatin, methacrylated silk fibroin, and dopamine\u2010mediated poly(3,4\u2010ethylenedioxythiophene) (PDA\u2010Fe\u2010PEDOT) conductive nanozymes. The PDA\u2010Fe\u2010PEDOT conductive nanozyme confers electrical conductivity to the hydrogel, enabling it to couple endogenous electrical signals at the wound site and transmit exogenous electrical signals to the wound. Additionally, the PDA\u2010Fe\u2010PEDOT nanozyme also imparts hydrogel peroxidase\u2010like activity, catalyzing hydrogen peroxide to generate hydroxyl radicals that effectively inhibit bacterial infection. The hydrogel also exhibits sustained antioxidant effects under exogenous electrical stimulation, reducing intracellular reactive oxygen species and protecting cells from oxidative stress. In vivo experiments demonstrated that vagus nerve electrical stimulation (VNS) regulates systemic inflammation, while the polyphenol\u2010conductive nanozyme\u2010enhanced redox hydrogel regulates local inflammation in diabetic wounds. The combination of polyphenol\u2010conductive nanozyme\u2010enhanced hydrogels and VNS synergistically promoted collagen deposition, angiogenesis, and nerve repair, leading to high\u2010quality wound healing in diabetic wounds, offering an innovative tissue repair strategy that integrates natural dressings with exogenous stimulation.<\/jats:p>","DOI":"10.1002\/adhm.202500027","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:37:54Z","timestamp":1746175074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Polyphenol Conductive Nanozyme\u2010Enhanced Redox Hydrogel Coupled with Vagus Nerve Electrical Stimulation for Diabetic Wound Repair"],"prefix":"10.1002","volume":"14","author":[{"given":"Jinhui","family":"Ran","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering 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