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Biodegradable material\u2010based nerve conduits have emerged as a promising alternative to address these limitations and enhance nerve regeneration. Among these materials, magnesium stands out due to its exceptional biocompatibility, biofunctionality, and neuroprotective properties. Despite its potential, magnesium's rapid corrosion rate and the need for controlled ion release necessitate advanced modifications, such as the development of Mg alloys. However, these approaches often face challenges, including viability concerns and material hardness, which can hinder nerve repair and damage surrounding tissues. In this study, a novel solution is introduced by sputtering magnesium onto a soft collagen sheet, achieving controlled magnesium ion release while preserving the material's nerve\u2010like softness. This Mg\u2010sputtered collagen sheet demonstrates excellent biocompatibility and significantly improves axon regeneration, muscle reinnervation, and functional recovery in a sciatic nerve defect model. These findings highlight the potential of an innovative Mg\u2010based biodegradable nerve conduit, offering transformative applications across various medical fields.<\/jats:p>","DOI":"10.1002\/adhm.202500063","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T01:34:27Z","timestamp":1745804067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Controlled Magnesium Ion Delivery via Mg\u2010Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"14","author":[{"given":"Hyewon","family":"Kim","sequence":"first","affiliation":[{"name":"Biomaterials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"},{"name":"Department of Biomicro System Technology Korea University  Seoul 02841 Republic of 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