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However, current multifunctional dressings can rarely accommodate multiple repair processes accurately due to the time\u2010dependent variational wound microenvironment. Herein, a Janus wound dressing is developed based on electrospun nanofibrous scaffold featuring programmed drug release performance and asymmetrical wettability. Specifically, polyvinylidene fluoride (PVDF) nanofiber membrane as the outer layer to resist the external biofouling and provide essential mechanical support for the inner layer was firstly constructed. Subsequently, the inner layer composed of polyvinyl pyrrolidone (PVP) and polylactic acid (PLA) fibers which are separately loaded with bacterial\u2010targeted nanoparticles (VHA NPs) and composite particle of zeolite imidazolate frameworks\u20108 containing deferoxamine (ZD NPs) is fabricated on the PVDF membrane. Experimental results demonstrated that the degradation rate of the inner layer could be precisely controlled to sequentially deliver the loaded drugs into the wound site. Taking advantages of the synergistic therapeutic effects including significant antibacterial activity, admired antioxidant property and remarkable angiogenesis performances, the fabricated Janus dressing (PF\/PHPD) achieves superior performance for promoting infected wound healing in a full\u2010thickness skin wound model, much better than that of conventional bandage and clinical antibiotic treated wound.<\/jats:p>","DOI":"10.1002\/adhm.202500188","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T13:09:59Z","timestamp":1753535399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Multifunctional Janus Electrospinning Dressing with Sequential Drug\u2010releasing Property for Programmed Treatments of Chronic Infected Wounds"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4712-4879","authenticated-orcid":false,"given":"Zhi","family":"Qu","sequence":"first","affiliation":[{"name":"School of Nursing Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Taian Shandong Province 271016 P. 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