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In recent years, growing evidence has shown that enhancing endogenous hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) synthesis or providing exogenous H<jats:sub>2<\/jats:sub>S can promote angiogenesis, inhibit inflammation, reduce excessive oxidative stress, and support collagen deposition. However, the administration of exogenous H<jats:sub>2<\/jats:sub>S often presents challenges related to controlling its release duration and achieving targeted delivery. To achieve controlled and site\u2010specific delivery of H<jats:sub>2<\/jats:sub>S to the wound area, a dual\u2010network cross\u2010linked injectable hydrogel formed by grafted \u03b5\u2010poly\u2010L\u2010lysine (designed as EG) and oxidized dextran (OD) (EGODF) loaded with a hydrogen sulfide donor (HSDF\u2010NH<jats:sub>2<\/jats:sub>) to study its potential in wound healing is developed. The hydrogel exhibits excellent injectability, self\u2010healing capability, and mechanical strength. Upon reactive oxygen species (ROS) stimulation, HSDF\u2010NH<jats:sub>2<\/jats:sub> releases both self\u2010reporter fluorescence (HSDG\u2010NH<jats:sub>2<\/jats:sub>) and H<jats:sub>2<\/jats:sub>S. Changes in the self\u2010reporter fluorescence signal reflect H<jats:sub>2<\/jats:sub>S production and its entry into the body to exert therapeutic effects. Finally, using a wound model and a hypertrophic scar repair model, it is demonstrated that EGODF hydrogel is effective in promoting wound healing and inhibiting scar production.<\/jats:p>","DOI":"10.1002\/adhm.202500264","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:53:01Z","timestamp":1746175981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dual\u2010Network Hydrogel Loaded With ROS\u2010activated Hydrogen Sulfide Donor to Accelerate Wound Healing and Inhibit Scar Production"],"prefix":"10.1002","volume":"14","author":[{"given":"Ziqiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Burns &amp; Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science Jinan University  Guangzhou 510006 China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University  Guangzhou 510006 China"},{"name":"College of Pharmacy Jinan University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Burns &amp; 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