{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:15:49Z","timestamp":1792268149710,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000217471"],"award-info":[{"award-number":["RS\u20102023\u201000217471"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite the great potential of photodynamic therapy (PDT), its success remains compromised by the abnormal redox homeostasis of tumor cells, which supports survival, growth, and resistance to oxidative therapeutic interventions by neutralizing reactive oxygen species (ROS). To overcome this barrier, a multifunctional prodrug nanomodulator (Pro@FLNC) is designed to induce disulfidptosis and immunogenic pyroptosis to trigger an antitumor immune response. Pro@FLNC features a prodrug core\u2013shell structure where ursolic acid (UA) and Chlorin e6 (Ce6) are conjugated via a GSH\u2010responsive linker and encapsulated in a DSPE\u2010PEG\u2010FA lipid shell for enhanced stability, biocompatibility, and tumor\u2010specific targeting. Within the tumor microenvironment (TME), Pro@FLNC depletes intracellular GSH, disrupts redox homeostasis, and releases Ce6 and UA, triggering oxidative stress and mitochondrial dysfunction. These mechanisms amplify ROS production, promote lipid peroxidation, and initiate disulfidptosis, evidenced by increased SLC7A11 expression and F\u2010actin collapse. Elevated ROS levels and metabolic imbalance\u2010triggered disulfidptosis further activate immunogenic pyroptosis, releasing damage\u2010associated molecular patterns (DAMPs) that stimulate dendritic cell maturation and cytotoxic T\u2010cell activation. Together, Pro@FLNC reshapes the TME, reduces immunosuppressive cells, and promotes CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration, effectively suppressing primary tumors and metastases. This programmed prodrug nanomodulator offers a promising strategy to enhance PDT and immunotherapy for advanced breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500272","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T04:49:36Z","timestamp":1742446176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Programable Prodrug Nanomodulator Targets Tumor Redox Homeostasis Imbalance to Amplify Disulfidptosis and Immunogenic Pyroptosis for Breast Tumor Immunotherapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6203-309X","authenticated-orcid":false,"given":"Ayeskanta","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP) Chonnam National University Medical School  Gwangju 61469 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-0578","authenticated-orcid":false,"given":"Adityanarayan","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP) Chonnam National University Medical School  Gwangju 61469 Republic of Korea"},{"name":"DR Cure Inc.  Hwasun 58128 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gwangju Institute of Science and Technology  Gwangju 61005 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gwangju Institute of Science and Technology  Gwangju 61005 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-2187","authenticated-orcid":false,"given":"Aravindkumar","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP) Chonnam National University Medical School  Gwangju 61469 Republic of Korea"},{"name":"DR Cure Inc.  Hwasun 58128 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Yeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Radiology Chonnam National University Medical School and Hwasun Hospital  322 Seoyang\u2010Ro Hwasun\u2010Gun, Jeollanam\u2010do 58128 Republic of Korea"},{"name":"DR Cure Inc.  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