{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:41:26Z","timestamp":1789792886441,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22467004"],"award-info":[{"award-number":["22467004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High\u2010fidelity kidney function imaging is important for assessing the nephrotoxicity of drugs and diagnosing renal diseases. However, the current challenges in achieving accurate kidney imaging include unspecific signal enhancement due to albumin binding and relatively low distribution of imaging agents in kidneys. Here, for the first time, a side\u2010chain engineering strategy that incorporates hydrophilic six\u2010membered heterocycles into aza\u2010hemicyanine for generating high\u2010performance kidney imaging agents with protein\u2010interference\u2010free and kidney\u2010targeting features is proposed. Based on these unique aza\u2010hemicyanine dyes, the first kidney\u2010targeting and albumin\u2010insensitive H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    near\u2010infrared (NIR) fluorescent probe NA\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    is designed, which demonstrates effective kidney distribution following intravenous injection and is specifically activated by H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    . The designed probe presents a highly rapid, selective and sensitive response to H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    with a detection limit as low as 24.21\u00a0n\n                    <jats:sc>m<\/jats:sc>\n                    . Additionally, it successfully achieves real\u2010time in vivo NIR fluorescence imaging of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    during erastin\/cisplatin induced renal ferroptosis. Moreover, it also enables rapid detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    through in vitro optical urinalysis, offering significant diagnostic value for renal ferroptosis. Overall, this study not only presents a practical kidney\u2010targeting H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    fluorescent probe NA\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    with increased imaging accuracy but also provides promising kidney\u2010targeting and albumin\u2010insensitive aza\u2010hemicyanine dyes for further development of kidney disease\u2010related probes.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500273","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T03:05:37Z","timestamp":1742871937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protein\u2010Interference\u2010Free and Kidney\u2010Targeting NIR Fluorophores for Accurate in Vivo Imaging of H\n                    <sub>2<\/sub>\n                    S\n                    <sub>2<\/sub>\n                    during Kidney Ferroptosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhangkang","family":"Lv","sequence":"first","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin 541004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin 541004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin 541004 P. R. 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