{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:45:34Z","timestamp":1785444334898,"version":"3.56.0"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471937"],"award-info":[{"award-number":["82471937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271927"],"award-info":[{"award-number":["82271927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202830"],"award-info":[{"award-number":["82202830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2021BS08002"],"award-info":[{"award-number":["2021BS08002"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCQNJC00620"],"award-info":[{"award-number":["23JCQNJC00620"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acquiring multidimensional tumor and tumor\u2010associated vascular information is essential for accurate diagnosis and treatment planning of glioma, yet effective imaging methods are still lacking. Here, ultrasmall manganese ferrite nanoparticles (UMFNs) are developed as a dual contrast\u2010enhanced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted imaging (T1WI) and susceptibility\u2010weighted imaging (SWI) probe for multidimensional diagnosis of glioma. The UMFNs are synthesized through thermal decomposition and functionalized with polyethylene glycol, ensuring excellent water dispersibility and biocompatibility. Characterization studies confirm the nanoparticles\u2019 uniform size (3.8\u00a0nm) and high stability in various media. High\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    (6.8 m\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:italic>*<\/jats:italic>\n                    (95.1 m\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) values demonstrate the superior\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    * enhancement capabilities of UMFNs. In vivo imaging on a 3.0 T magnetic resonance imaging (MRI) scanner demonstrates that UMFN\u2010enhanced SWI clearly delineates tumor margins and provides sustained tumor enhancement in ultrasmall orthotopic glioma (&lt;2\u00a0mm). Besides, UMFN\u2010enhanced SWI reveals distinct vascular structures associated with the glioma, including tortuous, thickened vessels indicative of tumor\u2010induced angiogenesis. Whole\u2010brain histological analysis corroborates these findings, demonstrating dense tumor proliferation and vascular remodeling. These results highlight the potential of UMFNs as a dual\u2010enhanced agent for the early detection and high\u2010resolution vascular mapping of glioma, providing an advanced multidimensional method for precise diagnosis of brain tumors.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500304","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:15:17Z","timestamp":1761624917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasmall Nanoprobe Enabling Contrast\u2010Enhanced\n                    <i>T<\/i>\n                    <sub>1<\/sub>\n                    \u2010Weighted and Susceptibility\u2010Weighted Imaging for Multidimensional Diagnosis of Glioma"],"prefix":"10.1002","volume":"15","author":[{"given":"Huanhuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin 300060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010kai","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medical Imaging School of Medical Technology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University  Tianjin 300203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-2543","authenticated-orcid":false,"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin 300060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1188\/16.CJON.S1.2-8"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.17"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052529"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0177-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105780"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21613"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02349-7"},{"key":"e_1_2_8_8_1","first-page":"107","volume":"9","author":"Gowtham P.","year":"2022","journal-title":"Nanomed. J."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab340"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbab062"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2024.06.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28662"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01479-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000187609.78338.dc"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0205-x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020212"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox175"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203071"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12360"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24768"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.08.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20598"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2013.0020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.787755"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185116637246"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2895-x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.12.021"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00112"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068445e"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.25220"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr01616a"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6262\/ad3b7a"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1740"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.014"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302856"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14050937"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2021.102486"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410414"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33550"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4tb00342j"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214809"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR05781C"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM02074F"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12598-023-02443-5"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29061352"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00039"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122550"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16111378"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.144542"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.125066"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b00736"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07684"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA06251H"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.12.067"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202400685"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31233"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c03424"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2007.08.010"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202400054"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5015"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01401-4"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107308"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202500304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:16:10Z","timestamp":1770794170000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202500304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adhm.202500304"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202500304","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00304"}}