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Unlike ROS, whose generation is limited by hypoxic conditions or insufficient H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels in the tumor, RCS can be generated through the electrochemical oxidation of abundant Cl<jats:sup>\u2212<\/jats:sup> present in body fluids. However, traditional electrochemical therapy modalities have shown suboptimal outcomes. Herein, a flexible anodic electrode is fabricated by growing a carbon nanowire network (C\u2010NWN) onto carbon cloth (CC). Attributing to its excellent hydrophilicity, high specific surface area, and electrochemical surface area, CC@C\u2010NWN demonstrates a superior capability for RCS generation. Additionally, the carbon vacancies in CC@C\u2010NWN not only enhance Cl<jats:sup>\u2212<\/jats:sup> adsorption but also reduce the reaction free energy of the chlorine evolution reaction (CER) more significantly compared to that of the oxygen evolution reaction, thereby promoting the CER process. RCS generated from the CC@C\u2010NWN electrochemical system induces severe oxidative stress, disrupting the redox homeostasis in tumor cells and promoting the synergistic anti\u2010tumor effect of apoptosis and ferroptosis. The pliability of CC@C\u2010NWN enables it to conform closely to the tumor, and it has demonstrated remarkable tumor\u2010suppressive efficacy under low\u2010voltage (3\u00a0V) condition in in vivo experiments. Therefore, the work holds significant promise for the development of novel tumor treatment strategies.<\/jats:p>","DOI":"10.1002\/adhm.202500369","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T15:30:27Z","timestamp":1748100627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carbon\u2010Based Flexible Electrode for Efficient Electrochemical Generation of Reactive Chlorine Species in Tumor Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8718-0803","authenticated-orcid":false,"given":"Cuinan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"National Innovation Center for Industry\u2010Education Integration of Energy Storage Technology MOE Key Laboratory of Low\u2010Grade Energy Utilization Technologies and Systems CQU\u2010NUS Renewable Energy Materials &amp; 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