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However, traditional patch\u2010clamp techniques are invasive and cannot capture the collective cell dynamics. While planar multielectrode arrays (MEAs) offer a non\u2010invasive alternative, they suffer from poor cell\u2010electrode coupling and limited resolution for identifying specific DRG neuronal types like C\u2010fiber nociceptors, key targets in chronic pain research. This work demonstrates that silicon nanowire (SiNW) mat\u2010based MEAs, while maintaining their reduced invasiveness, enable continuous intracellular recordings from neurons in primary rat DRG cell cultures. Supported by a cortical astrocyte feeder layer, SiNW mats promote DRG neuron and glial cell growth preserving cells\u2019 in vivo morphological and functional characteristics. Integrated into a compartmentalized MEA, they enable reliable recordings of drug\u2010modulated neuronal activity alongside a baseline related to the astrocyte layer. The recorded signals exhibit characteristics of intracellular action potentials, suggesting spontaneous intracellular access by SiNWs. Distinct electrophysiological signatures allow identifying C\u2010fiber nociceptors, as confirmed by patch\u2010clamp measurements. 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