{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:21:58Z","timestamp":1786976518624,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biomechanical complications, such as stress shielding, bone resorption, and reconstruction failure, are prevalently associated with solid titanium mandible reconstruction plates. This study evaluates the potential of metamaterial designs with porous gyroid microarchitectures, to enhance biomechanical stimulation and mitigate these complications. A novel metamaterial reconstruction plate is compared with solid titanium plates, both patient\u2010specifically designed and fabricated from Ti6Al4\u00a0V alloy. Stress shielding is assessed through photoelasticity experiments and validated with finite element analysis (FEA). Transparent mandible models are loaded incrementally (0\u20131000 N) to analyze stress distributions in the implants, screws, and mandible segments. The metamaterial plate reduces stress concentrations in the distant mandibular regions from the defect, while increasing stress around the screws near the defect, favoring local mechanical stimulation. FEA confirms improved load distribution (p = 0.003). However, the metamaterial plate exhibited a lower load\u2010bearing capacity, failing at 775 N, while the solid plate withstood 1800 N without failure. Yet, the metamaterial design effectively reduced stress shielding, thereby enhancing biomechanical function near critical mandibular regions. Hence, despite their reduced load\u2010bearing capacity, they can, potentially, preserve bone integrity and prevent implant failure that should be validated in future (pre\u2010)clinical studies.<\/jats:p>","DOI":"10.1002\/adhm.202500405","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T12:02:13Z","timestamp":1743854533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mandibular Implants: A Metamaterial\u2010Based Approach to Reducing Stress Shielding"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-109X","authenticated-orcid":false,"given":"Jorn\u2010Ids","family":"Heins","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen University Medical Center Groningen  Groningen 9713 GZ The Netherlands"},{"name":"3D Lab University Medical Center Groningen University of Groningen  Groningen 9713 GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-3104","authenticated-orcid":false,"given":"Bram B.J.","family":"Merema","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen University Medical Center Groningen  Groningen 9713 GZ The Netherlands"},{"name":"3D Lab University Medical Center Groningen University of Groningen  Groningen 9713 GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-960X","authenticated-orcid":false,"given":"Joep","family":"Kraeima","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen University Medical Center Groningen  Groningen 9713 GZ The Netherlands"},{"name":"3D Lab University Medical Center Groningen University of Groningen  Groningen 9713 GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-3246","authenticated-orcid":false,"given":"Max J.H.","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University of Groningen University Medical Center Groningen  Groningen 9713 GZ The Netherlands"},{"name":"3D Lab University Medical Center Groningen University of Groningen  Groningen 9713 GZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-2592","authenticated-orcid":false,"given":"Anastasiia O.","family":"Krushynska","sequence":"additional","affiliation":[{"name":"Engineering and Technology Institute Groningen University of Groningen  Groningen 9747AG The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2023.103959"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compstruct.2022.116379"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2022.105291"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2022.105422"},{"key":"e_1_2_8_5_1","first-page":"211","volume-title":"Mechanical Properties of Bone","author":"Huiskes R.","year":"1981"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mechrescom.2023.104094"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/pr10030612"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20705"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05440-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23445"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.06.001"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8686670"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000096825.67494.e3"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6183679"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2018.01.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.11.011"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03080-1"},{"key":"e_1_2_8_11_4","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-03857-y"},{"key":"e_1_2_8_11_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2019.07.016"},{"key":"e_1_2_8_11_6","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13381"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-82964-w"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00161-023-01240-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2013.04.006"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812524-3.00008-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.10.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MH00699C"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03492-9"},{"key":"e_1_2_8_15_3","volume":"7","author":"Chen J.","year":"2024","journal-title":"Int. J. Extreme Manufactur."},{"key":"e_1_2_8_15_4","doi-asserted-by":"publisher","DOI":"10.1111\/os.14142"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/nanoph-2022-0671"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2023.112554"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmecsci.2021.106331"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1092361"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/1402-4896\/ad818e"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compstruct.2023.117262"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma17010140"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41524-020-0341-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202203533"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2024.12.018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c17625"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1081286520978516"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb16020054"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00979.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/174028"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-015-0766-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0229080"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40964-024-00714-w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2019.1569638"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04310-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1557\/mrs.2019.228"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0129765"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(93)90042-D"},{"key":"e_1_2_8_33_1","first-page":"256","volume":"8","author":"Hou C.","year":"2024","journal-title":"J. Manufactur. Mater. Process."},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11340-015-0021-5"},{"key":"e_1_2_8_33_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2019.108165"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/met10050648"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma15196819"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.104157"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.06.306"},{"key":"e_1_2_8_35_3","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2016.1240788"},{"key":"e_1_2_8_35_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.06.218"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1374647"},{"key":"e_1_2_8_36_2","first-page":"700","volume":"9","author":"Poli O.","year":"2021","journal-title":"MDPI"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.03.057"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40846-018-0370-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.606947"},{"key":"e_1_2_8_40_1","first-page":"175","volume":"64","author":"Frost H. M.","year":"1994","journal-title":"Angle Orthod"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-020-00889-w"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-022-02657-2"},{"key":"e_1_2_8_41_3","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-024-01289-x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.01.024"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1081286516644867"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:23:59Z","timestamp":1759775039000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202500405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":73,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/adhm.202500405"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202500405","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"2025-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2500405"}}