{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:18:05Z","timestamp":1792027085352,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973662"],"award-info":[{"award-number":["81973662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Achieving direct delivery of drugs to the tumor site is a prerequisite for successful drug development, necessitating that drug molecules be cell permeable. Numerous studies have shown that cell\u2010penetrating peptides (CPPs) can augment the efficacy of various therapeutic agents by enhancing cellular uptake, prompting their advancement into preclinical studies. However, the non\u2010specificity and cationic properties of CPPs impede their clinical application. Attributed to the easily accessible capacity and excellent biocompatibility of red blood cells (RBC), herein, an RBC membrane camouflaged, cell\u2010penetrating peptides R8\u2010(RRRRRRRR)based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), thus precisely inducing tumor inhibition. The RBC membrane camouflaged nanosystem escaped from the reticuloendothelial system (RES) and is endocytosed by tumor cells mediated by R8. Released TP and Cel\u2010induced tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer. Overall, the biomimetic nanosystem realizes enhanced drug combination therapy with high\u2010level biosafety, which provides a facile strategy to improve the clinical application of CPPs\u2010based drug combinations.<\/jats:p>","DOI":"10.1002\/adhm.202500446","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T06:36:23Z","timestamp":1746599783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["RBC Membrane\u2010Camouflaged Nanosystem\u2010Mediated Synergistic Drug Combination for Enhanced Anti\u2010Tumor Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Qian","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxizi","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-4241","authenticated-orcid":false,"given":"Ruibing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Taipa Macau SAR 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312169"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0566-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02681-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00848"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2013.875029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140617092552"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040531"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-018-2084-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106634108"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13663"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00893"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.03.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00104"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5411"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b03148"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.056"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.04.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00934-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300159u"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200138"},{"key":"e_1_2_8_24_1","first-page":"3252","volume":"56","author":"Zhong X.","year":"2021","journal-title":"J. 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