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However, existing NO\u2010releasing catheters face challenges, including maintaining stable NO release over time and complex manufacturing processes. In this study, a robust nanocoating made from tannic acid (TA) and selenocystamine (SeCA) is presented, designed to catalytically generate NO from\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosoglutathione in the presence of glutathione. Surface characterization techniques confirmed successful coating formation, with optimal NO generation achieved at a 1:4 TA:SeCA molar ratio. The coated catheters maintained over 96% viability of human coronary artery smooth muscle cells (HCASMCs) after 72\u00a0h. It has been demonstrated that the modified catheters significantly increased endogenous NO production in HCASMCs from intracellular\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosothiols, highlighting their potential to support vascular function. The coating sustained NO release at 7 \u00d7 10\n                    <jats:sup>\u221210<\/jats:sup>\n                    \u00a0mol\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    \u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    for at least 3 days, exceeding the typical release rate of healthy endothelium. Notably, the coating effectively reduced pro\u2010inflammatory cytokine (TNF\u2010\u03b1 and IL\u20106) production in RAW 264.7 macrophages upon lipopolysaccharide stimulation, demonstrating anti\u2010inflammatory effects. This material\u2010driven approach simplifies NO delivery and offers an effective strategy to enhance catheter efficacy to support vascular function and minimize inflammation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500457","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:23:33Z","timestamp":1756466613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nitric Oxide\u2010Releasing Catheters with Phenol\u2010Amine Catalytic Coatings for Improved Anti\u2010Inflammatory Performance"],"prefix":"10.1002","volume":"14","author":[{"given":"Qingqing","family":"Fan","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales  Sydney NSW 2052 Australia"},{"name":"Department of Chemical Engineering The University of Melbourne  Parkville VIC 3010 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