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Despite its global impact, a standardized clinical treatment protocol remains undeveloped. In this study, novel selenium nanoparticles (SeNPs) are synthesized using <jats:italic>Lactobacillus coryniformis<\/jats:italic> ES23 (<jats:italic>L. coryniformis<\/jats:italic> ES23). It is found that SeNPs significantly mitigate liver steatosis, inflammation, and fibrosis induced by a choline\u2010deficient, L\u2010amino\u2010acid\u2010defined, high\u2010fat diet (CDAHFD). Mechanistically, SeNPs regulate fatty acid and triglyceride metabolism through the peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1) pathway. Moreover, these results show that SeNPs maintain iron homeostasis by reducing the expression of heme oxygenase 1 (HMOX1) and transferrin receptor (TFRC), therefore decreasing iron accumulation and inhibiting ferroptosis in the mouse liver. Taken all, the findings in this study suggest that SeNPs can serve as a novel therapeutic approach for treating MASH via modulating lipid metabolism and ferrous ion homeostasis.<\/jats:p>","DOI":"10.1002\/adhm.202500467","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T01:30:32Z","timestamp":1749173432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biomimetic Selenium\u2010Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhanpeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Hubei Minzu University Affiliated Enshi Clinical Medical School The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Hubei Selenium and Human Health Institute the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture  Enshi 445000 China"},{"name":"Hubei Provincial Key Lab of Selenium 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