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However, many commonly used photosensitizers (PSs) have the disadvantages of poor water\u2010solubility and potential toxicity, which limits their clinical application. Additionally, nitric oxide (NO) has unique advantages in antibacterial treatments due to its small molecular weight. Herein, protoporphyrin IX (PpIX), L\u2010arginine (L\u2010Arg), and glycol chitosan (GC) are used to construct a self\u2010assembled cationic Arg\u2010GC\u2010PpIX nanoreactor for efficient bacterial inactivation under white light illumination. The Arg\u2010GC\u2010PpIX nanoreactor with excellent water dispersity and stability can rapidly bind to bacteria through electrostatic interaction and produce local singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>)\/NO under light irradiation, leading to a high antibacterial efficiency toward both Gram\u2010negative and Gram\u2010positive bacteria. Besides, these NPs also possess a desirable antibiofilm ability. Finally, Arg\u2010GC\u2010PpIX@Gel which is obtained through loading Arg\u2010GC\u2010PpIX into the sodium alginate (SA)\/Ca<jats:sup>2+<\/jats:sup> hydrogel shows a satisfactory ability to promote infected wound healing when combined with white light irradiation. Therefore, the rationally designed Arg\u2010GC\u2010PpIX nanoreactor\u00a0with light\u2010triggered <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>\/NO release is a promising antibacterial agent for achieving effective PDT\/NO gas therapy.<\/jats:p>","DOI":"10.1002\/adhm.202500487","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T01:25:34Z","timestamp":1745803534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Self\u2010Assembled Nanoreactor for Realizing Antibacterial Photodynamic\/Gas Therapy and Promoting Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Chenyang","family":"Jia","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University  2 Southeast University Road Nanjing 211189 P. R. 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