{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:53:14Z","timestamp":1789051994711,"version":"build-2803163510"},"reference-count":160,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RGS\u2216R2\u2216242300"],"award-info":[{"award-number":["RGS\u2216R2\u2216242300"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The global increase in chronic diseases and comorbidities due to aging populations is placing significant strain on healthcare systems. Chronic kidney disease (CKD) and osteoarthritis (OA) are among the most prevalent conditions in the elderly, with complex interconnections driven by shared risk factors such as systemic inflammation and metabolic dysregulation. Despite the critical need to understand these interactions, traditional animal models often fail to adequately capture the multidirectional crosstalk between human comorbid conditions, limiting insights into their mechanisms and complicating translational research. Advancements in microphysiological systems (MPS), which also known as organ\u2010on\u2010a\u2010chip (OoC) technologies, offer a promising alternative for studying comorbidities, such as CKD\u2010OA. MPS, which integrate human cells within biomimetic, bioengineered platforms, replicate the structural and functional properties of human tissues with unparalleled physiological relevance. This review explores the transformative potential of MPS technology in comorbidity research, focusing on CKD\u2010OA as a case study. Kidney\u2010on\u2010a\u2010chip and joint\u2010on\u2010a\u2010chip models and their applications in CKD and OA modeling are summarized and discussed. Furthermore, multi\u2010organ\u2010on\u2010a\u2010chip systems are = discussed for their potential to model\u00a0comorbidities = and support the development of safer and more effective disease treatment strategies. This review underscores the potential of MPS to revolutionize comorbidity research and pave the way for personalized therapies.<\/jats:p>","DOI":"10.1002\/adhm.202500550","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T02:27:40Z","timestamp":1751250460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-2337","authenticated-orcid":false,"given":"Mingying","family":"Han","sequence":"first","affiliation":[{"name":"Department of Materials Design and Manufacturing Engineering School of Engineering University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-3919","authenticated-orcid":false,"given":"Weiping","family":"Lin","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine and Health Hong Kong Institute of Science and Innovation CAS Ltd. Fifth Affiliated Hospital of Guangzhou Medical University  China"},{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London  London E1 2AD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Physiology Anatomy and Genetics Kavli Institute for Nanoscience Discovery University of Oxford  Oxford OX1 3QU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Institute of Life Course and Medical Sciences University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Wilm","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Institute of Life Course and Medical Sciences University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"McWilliam","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Institute of Life Course and Medical Sciences University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Materials Design and Manufacturing Engineering School of Engineering University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1000-8960","authenticated-orcid":false,"given":"Ruoxiao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Materials Design and Manufacturing Engineering School of Engineering University of Liverpool  Liverpool L69 UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02296-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97756-z"},{"key":"e_1_2_8_4_1","first-page":"79","volume":"13","author":"Totlibayevich Y. S.","year":"2022","journal-title":"Texas J. Med. Sci."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2024.07.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00163-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00066-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173515"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5680"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2021.0440"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03792-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.101249"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.33.321.18114"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03672-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2014.06.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00539-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00098.2016"},{"key":"e_1_2_8_19_1","first-page":"223","volume":"37","author":"Cassotta M.","year":"2020","journal-title":"ALTEX\u2010Alterna. Anim. Exp."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.06.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148551"},{"key":"e_1_2_8_22_1","volume":"7","author":"Lee W. C.","year":"2018","journal-title":"J. Clin. Med."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab8bc3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering5020043"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7IB00024C"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00241J"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12650"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00957K"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.03.025"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2019.12.010"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi7070120"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5037968"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.602646"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01236-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.029"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0034-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08879-x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC00689D"},{"key":"e_1_2_8_42_1","unstructured":"B.Koeppen B.Stanton Elsevier Health Sciences Amsterdam The Netherlands2012."},{"key":"e_1_2_8_43_1","volume-title":"Seldin and giebisch's the kidney: Physiology & pathophysiology","author":"Alpern R. J.","year":"2007"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.12.002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1494-0"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10391012"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2015.06.020"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2180373"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1844-7"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft071"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi7070126"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-052521-121841"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0038-3"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.01.018"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00521.2005"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188302"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0069"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4946870"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11577-z"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b01097"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100031"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050113"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.11.007"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402195111"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101612"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp0603513"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/B907515A"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/b915147h"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24339"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.03.105"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.27.907"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.743"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.03.017"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.05.12.491717"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-016-9871-8"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2021.01.028"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-018-0248-z"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202200143"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00723A"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0882-y"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90405.2008"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.11.001"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19293-3"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34845"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815208116"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16590-9"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0325-y"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.01.009"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305322120"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy159"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.2741\/4337"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00164.2016"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050311-163340"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050513"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.149"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118807"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.92"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350726"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000067652.51441.21"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.88"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03191-5"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.010"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120555"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0047"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3182745993"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc20982a"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812952-4.00004-0"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC01069G"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900291"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.029"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00411"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.03.003"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC00130B"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.137123"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2022.105444"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100948"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00375-z"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05359-9"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1013-2"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-06216-w"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00700-4"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215157"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.064"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42678"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31658-0"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00736-6"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1125405"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.01.552"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.06.019"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.643"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0406-3"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac0c5e"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01852J"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0500-6"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95978"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00882-6"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00259.2002"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46787-7"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612906114"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-022-00523-z"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S191156"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab067"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.03.013"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0068-7"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00749-9"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041567"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160225"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3804-5"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1557\/mrc.2018.148"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06454-7"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2021.06.001"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65817-0"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13110775"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC00392J"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20575.1"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20884"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2407439121"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c00383"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202500550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:58:38Z","timestamp":1781755118000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202500550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":160,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/adhm.202500550"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202500550","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,29]]},"assertion":[{"value":"2025-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2500550"}}