{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:16:52Z","timestamp":1783340212886,"version":"3.54.6"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multifunctional hydrogels have aroused great interest in accelerating wound healing. In this study, a hydrogel dressing with antioxidant, antibacterial, anti\u2010inflammatory, and wound healing properties is developed using xylose (Xy) glycated Chinese giant salamander collagen (CGSPXy), curcumin (Cur), sodium alginate (SA), and chitosan (CS). Specifically, the CGSP\/CGSPXy\u2010Cur nanoparticle is mixed with SA through hydrogen bonding interactions to form a hydrogel framework. Subsequently, the CGSP\/CGSPXy\u2010Cur\u2010SA is immersed in a solution containing Ca\n                    <jats:sup>2<\/jats:sup>\n                    \u207a and CS, forming an ion\u2010crosslinked semi\u2010interpenetrating double\u2010network hydrogel. Notably, CGSPXy synergized with Cur reduced the swelling ratio while enhancing the thermal stability, rheological properties, adhesion performance, and tensile strength of hydrogels. In\n                    <jats:italic>vitro<\/jats:italic>\n                    experiments demonstrated that hydrogels constructed with CGSPXy\u2010Cur nanoparticles exhibited sustained Cur release, along with excellent blood compatibility, clotting properties, antioxidant, and antibacterial activity. Also, CGSPXy synergized with Cur has been proven to effectively promote wound healing by promoting collagen deposition, new blood vessels, myofibroblast generation, and reducing the production of proinflammatory factors (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL\u20106). This study provided a promising strategy for collagen\u2010based hydrogel as a sustainable solution for wound care.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500554","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T07:51:53Z","timestamp":1757749913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multifunctional Hydrogel Dressing Based on Glycosylated Collagen\u2010Curcumin Nanoparticles Effectively Accelerates Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Jing\u2010Jing","family":"Fu","sequence":"first","affiliation":[{"name":"School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou Zhejiang 310035 China"},{"name":"Zhejiang Provincial Collaborative Innovation Center of Food Safety and Nutrition Zhejiang Gongshang University  Hangzhou Zhejiang 310035 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Gongshang University  Hangzhou Zhejiang 310035 China"},{"name":"Zhejiang Provincial Collaborative Innovation Center of Food Safety and Nutrition Zhejiang Gongshang University  Hangzhou Zhejiang 310035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Chu","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou Zhejiang 310035 China"},{"name":"Zhejiang Provincial Collaborative Innovation Center of Food Safety and Nutrition Zhejiang Gongshang University  Hangzhou Zhejiang 310035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou Zhejiang 310035 China"},{"name":"Zhejiang Provincial Collaborative Innovation Center of Food Safety and Nutrition Zhejiang Gongshang University  Hangzhou Zhejiang 310035 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