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Tumor vasodilation and ensuring deep drug delivery are essential to elevating tumor elimination efficiency. Herein, a powerful nanoregulator is reported with tumor vessel vasodilation and tumor microenvironment (TME) reconstruction capacity for photoacoustic\/magnetic resonance imaging\u2010guided tumor starvation and ferroptosis therapy. This nanoregulator uses ultra\u2010small ferrous sulfide (FeS) nanoparticles as a Fenton agent and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) as a donor. Additionally, glucose oxidase (GOx) serves as a glucose\u2010depleting agent and poly (lactic\u2010co\u2010glycolic) acid (PLGA) functions as a building block. PLGA@ultra\u2010small FeS\u2010GOx nanoregulators can simultaneously promote accumulation and enhance penetration deep into tumors through H<jats:sub>2<\/jats:sub>S\u2010induced vasodilation and acid\u2010responsive degradation. 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