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These issues can lead to wound contamination and the risk of secondary injuries. In this work, a robust, thermoresponsive wound dressing is developed based on pH\/thermal\u2010responsive supramolecular hydrogels, synthesized by integrating N\u2010isopropyl acrylamide, carboxymethyl cellulose, and \u03b2\u2010cyclodextrin\u2010grafted poly(acrylic acid). The novel finding is that the hydrogel exhibits a Janus\u2010like adhesion, wherein it adheres stably to the wound while losing adhesion to external environments resulting in reduced accumulation of impurities. The prepared hydrogels can self\u2010heal at low temperatures. It has antioxidant properties and excellent biocompatibility that can continuously and stably release active medicines. In vivo experiments in a rat model of full\u2010thickness skin wounds show that the hydrogels positively accelerate wound healing. The unique physicochemical properties and biological interactions of this multifunctional supramolecular hydrogel provide a promise for advancing wound management by modulating tissue adhesion.<\/jats:p>","DOI":"10.1002\/adhm.202500600","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:48:01Z","timestamp":1746175681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Fabrication of Janus\u2010adhesion Multifunctional Hydrogel Based on \u03b2\u2010cyclodextrin for Wound Dressing"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-6826","authenticated-orcid":false,"given":"Juanli","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou 510640 P. R. 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