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However, to leverage such an approach to its full potential, high colloidal stability of the nanoparticles in the absence of a magnetic field for optimal binding, and rapid and quantitative recovery upon magnetic gradient field application are imperative. While these properties are mutually exclusive for conventional nanoparticles synthesized by wet\u2010chemistry approaches, sputter deposition gives access to layered architectures featuring the properties of a synthetic antiferromagnet (SAF, no magnetization in zero field, high magnetization upon field application).<\/jats:p>\n                  <jats:p>Here, micromagnetic\u2010modelling based design optimization and scalable manufacturing of metallic CoSm\u2010based, metal oxide\u2010capped SAF magnetic disk particles (SAF MDPs) with high chemical and colloidal stability and cytocompatibility are presented. It is demonstrated that the SAF MDPs can be rapidly and much more efficiently separated () from flowing fluids (approx. 1\u00a0mL\/min) compared to corresponding gold standard iron oxide beads ( recovery), paving the way to quantitative capturing and enrichment of target compounds in high\u2010throughput conditions compliant with clinical and industrial\u00a0applications.<\/jats:p>","DOI":"10.1002\/adhm.202500616","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:35:05Z","timestamp":1754897705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthetic Antiferromagnetic Designer Nanodisks for High\u2010Performance Magnetic Separation"],"prefix":"10.1002","volume":"14","author":[{"given":"Subas","family":"Scheibler","sequence":"first","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT), ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Nanomaterials in Health Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland"},{"name":"Magnetic &amp; Functional Thin Films Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) D\u00fcbendorf 8600 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Habermann","sequence":"additional","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT), ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Nanomaterials in Health Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland"},{"name":"Faculty of Medicine University of Zurich Raemistrasse 71 Zurich 8006 Switzerland"},{"name":"Ingenuity Lab Balgrist University Hospital Forchstrasse 340 Zurich 8008 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gogos","sequence":"additional","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT), ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Nanomaterials in Health Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland"},{"name":"Faculty of Medicine University of Zurich Raemistrasse 71 Zurich 8006 Switzerland"},{"name":"Ingenuity Lab Balgrist University Hospital Forchstrasse 340 Zurich 8008 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Helbig","sequence":"additional","affiliation":[{"name":"Physics of Functional Materials, Faculty of Physics University of Vienna Boltzmanngasse 5 Vienna 1090 Austria"},{"name":"Research Platform MMM Mathematics \u2013 Magnetism \u2013 Materials University of Vienna Oskar\u2010Morgenstern\u2010Platz 1 Vienna 1090 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas R. 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Radzikowskiego 152 Krakow 31\u2010342 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alinezhadfar","sequence":"additional","affiliation":[{"name":"Surface Science and Coating Technologies Laboratory, Department of Advanced Materials and Surfaces Swiss Federal Laboratories for Materials Science and Technology (Empa) D\u00fcbendorf 8600 Switzerland"},{"name":"Durability of Engineering Materials, Institute for Building Materials (IfB), Department of Civil, Environmental and Geomatic Engineering (D\u2010BAUG) ETH Zurich Zurich 8093 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena","family":"Crockett","sequence":"additional","affiliation":[{"name":"Surface Science and Coating Technologies Laboratory, Department of Advanced Materials and Surfaces Swiss Federal Laboratories for Materials Science and Technology (Empa) D\u00fcbendorf 8600 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Kummer","sequence":"additional","affiliation":[{"name":"Laboratory of Food Process Engineering, Institute of Food, Nutrition and Health (IFNH) Department for Health Sciences and Technology (D\u2010HEST) ETH Zurich Schmelzbergstrasse 9 Zurich 8092 Switzerland"},{"name":"Laboratory for Cellulose and Wood Materials, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) \u00dcberlandstrasse 129 D\u00fcbendorf 8600 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik M.","family":"Mayr","sequence":"additional","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT), ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Nanomaterials in Health Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland"},{"name":"Magnetic &amp; Functional Thin Films Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) D\u00fcbendorf 8600 Switzerland"},{"name":"Faculty of Medicine University of Zurich Raemistrasse 71 Zurich 8006 Switzerland"},{"name":"Ingenuity Lab Balgrist University Hospital Forchstrasse 340 Zurich 8008 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"S\u00fcss","sequence":"additional","affiliation":[{"name":"Physics of Functional Materials, Faculty of Physics University of Vienna Boltzmanngasse 5 Vienna 1090 Austria"},{"name":"Research Platform MMM Mathematics \u2013 Magnetism \u2013 Materials University of Vienna Oskar\u2010Morgenstern\u2010Platz 1 Vienna 1090 Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Hug","sequence":"additional","affiliation":[{"name":"Magnetic &amp; Functional Thin Films Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) D\u00fcbendorf 8600 Switzerland"},{"name":"Department of Physics University of Basel Basel CH\u20104056 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4655-6807","authenticated-orcid":false,"given":"Inge K.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT), ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Nanomaterials in Health Laboratory, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland"},{"name":"Faculty of Medicine University of Zurich Raemistrasse 71 Zurich 8006 Switzerland"},{"name":"Ingenuity Lab Balgrist University Hospital Forchstrasse 340 Zurich 8008 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm00994f"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.COLSURFB.2020.111014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006388117"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000438"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01272H"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b10140"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00233"},{"key":"e_1_2_8_8_1","unstructured":"CELLSEARCH https:\/\/www.cellsearchctc.com. 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