{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:15:16Z","timestamp":1787062516504,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260428"],"award-info":[{"award-number":["82260428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011744","name":"National University Health System","doi-asserted-by":"publisher","award":["NUHSRO\/2022\/087\/RO5+6\/Seed\u2010Sep\/03"],"award-info":[{"award-number":["NUHSRO\/2022\/087\/RO5+6\/Seed\u2010Sep\/03"]}],"id":[{"id":"10.13039\/501100011744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Avascular necrosis of the femoral head (ANFH) is a debilitating musculoskeletal disorder that is typically caused by impaired blood supply to the hip joint. In treating irregular bone defects that resulted from ANFH, injectable hydrogels are particularly attractive as they can be administered in a minimally invasive manner and conform to the variable shape of a bone defect. However, they often lack the biochemical and mechanical properties for effective bone repair. To address these issues, an injectable composite hydrogel, SA\/\u03b2\u2010TCP@PMP, composed of sodium alginate (SA) and \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) crosslinked with glucono\u2010delta\u2010lactone (GDL), and enforced with varying concentrations of poly(3\u2010hydroxybutyrate\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u20104\u2010hydroxybutyrate)\/magnesium oxide and polyethylene glycol (P34HB\/MgO+PEG; PMP) coaxial electrospun microfibers are formulated. By varying the concentrations (0%, 1%, 2%, 4%) of PMP microfibers, the physical properties of the composite hydrogel, including its injectability, surface morphology, swelling, degradation, and mechanical properties, as well as magnesium ions (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ) release can be finely tuned. Among all, SA\/\u03b2\u2010TCP@2%PMP composite hydrogel demonstrates superior angiogenic and osteogenic properties, and promotes robust new bone formation in a rabbit model of steroid\u2010induced ANFH. Overall, this novel composite hydrogel offers significant application potential for minimally invasive treatment of irregular bone lesions in ANFH.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202500617","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:09:31Z","timestamp":1747627771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Injectable Alginate\/\u03b2\u2010TCP Composite Hydrogel Incorporating P34HB\/MgO+PEG Coaxial Electrospun Microfibers for Minimally Invasive Treatment of Osteonecrosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-0963","authenticated-orcid":false,"given":"Yu Hu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Hao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Xiang","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"},{"name":"Center for Tissue Engineering and Stem Cell Research Guizhou Medical University  Guiyang Guizhou 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"},{"name":"Center for Tissue Engineering and Stem Cell Research Guizhou Medical University  Guiyang Guizhou 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-3177","authenticated-orcid":false,"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Guizhou Medical University  No. 28 Guiyi Street Guiyang 550004 China"},{"name":"Center for Tissue Engineering and Stem Cell Research Guizhou Medical University  Guiyang Guizhou 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-6423","authenticated-orcid":false,"given":"Wei Seong","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Road Singapore 119228 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.03.012"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.01582"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.04.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2020.03.040"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-022-05418-w"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00196-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.01271"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00179"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123232"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112130"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.08.066"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.10.056"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00566"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00709"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202401"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401953"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111156"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.06.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c21260"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.769"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213864"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212759"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2011.0271"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.106737"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.110349"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108300"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117119"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm060010d"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2014.07.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.008"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122184"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109927"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112208"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2020.109232"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.08.028"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB02553D"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.051"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00901F"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.12.004"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b05460"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.10.005"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.04.023"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.031"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127481"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110294"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110266"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202200011"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.025"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00104J"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c08784"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S216182"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.04.045"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X11666160815095733"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105776"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.01.002"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.06.009"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2875"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300685"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202500617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:30:44Z","timestamp":1759761044000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202500617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":60,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/adhm.202500617"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202500617","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2500617"}}